J 2018

Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

ŠPLÍCHAL, Zbyněk, Filip ZLÁMAL, Jan MÁCHAL, Jolana LIPKOVÁ, Tereza PAVLOVÁ et. al.

Basic information

Original name

Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

Authors

ŠPLÍCHAL, Zbyněk (203 Czech Republic, guarantor, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Tereza PAVLOVÁ (203 Czech Republic, belonging to the institution), Zuzana HODICKÁ (203 Czech Republic), Pavel VENTRUBA (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, LONDON, INFORMA HEALTHCARE, 2018, 1476-7058

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.569

RIV identification code

RIV/00216224:14110/18:00102134

Organization unit

Faculty of Medicine

DOI

UT WoS

000430732400003

Keywords in English

Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM

Tags

Tags

International impact, Reviewed
Změněno: 26/3/2019 10:44, Soňa Böhmová

Abstract

V originále

Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.

Links

EF15_003/0000469, research and development project
Name: Cetocoen Plus
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR