Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

ŠPLÍCHAL, Zbyněk, Filip ZLÁMAL, Jan MÁCHAL, Jolana LIPKOVÁ, Tereza PAVLOVÁ, Zuzana HODICKÁ, Pavel VENTRUBA, Anna VAŠKŮ and Julie BIENERTOVÁ VAŠKŮ. Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. LONDON: INFORMA HEALTHCARE, 2018, vol. 31, No 13, p. 1689-1695. ISSN 1476-7058. Available from: https://dx.doi.org/10.1080/14767058.2017.1323530.

Basic information

• Original name: Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
• Authors: ŠPLÍCHAL, Zbyněk (203 Czech Republic, guarantor, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Tereza PAVLOVÁ (203 Czech Republic, belonging to the institution), Zuzana HODICKÁ (203 Czech Republic), Pavel VENTRUBA (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution).
• Edition: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, LONDON, INFORMA HEALTHCARE, 2018, 1476-7058.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30214 Obstetrics and gynaecology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.569
• RIV identification code: RIV/00216224:14110/18:00102134
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1080/14767058.2017.1323530
• UT WoS: 000430732400003
• Keywords in English: Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM
• Tags: 14110518, EL OK, podil, rivok
• Tags: International impact, Reviewed

Abstract

Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.

Links

• EF15_003/0000469, research and development project: Name: Cetocoen Plus
• LM2015051, research and development project: Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR