BIENERTOVÁ VAŠKŮ, Julie, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej MIKEŠ, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK, Zbyněk ŠPLÍCHAL and Hynek PIKHART. Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. BMC Medical Genetics. ENGLAND: BIOMED CENTRAL LTD, 2017, vol. 18, No 90, p. 1-9. ISSN 1471-2350. Available from: https://dx.doi.org/10.1186/s12881-017-0454-z.
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Basic information
Original name Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population
Authors BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Aneta POHOŘALÁ (203 Czech Republic, belonging to the institution), Ondřej MIKEŠ (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution) and Hynek PIKHART (203 Czech Republic, belonging to the institution).
Edition BMC Medical Genetics, ENGLAND, BIOMED CENTRAL LTD, 2017, 1471-2350.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30101 Human genetics
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.913
RIV identification code RIV/00216224:14110/17:00098762
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1186/s12881-017-0454-z
UT WoS 000408145600001
Keywords in English VDR; SNP; Obesity; Anthropometry; Adiposity; Gene; Vitamin D; Polymorphism; Adiposity measure
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 7/3/2018 16:04.
Abstract
Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
Links
EF15_003/0000469, research and development projectName: Cetocoen Plus
LM2015051, research and development projectName: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
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