Allelic variants in vitamin D receptor gene are associated with
adiposity measures in the central-European population

J 2017

Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population

BIENERTOVÁ VAŠKŮ, Julie, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej MIKEŠ, Monika PÁVKOVÁ GOLDBERGOVÁ et. al.

Basic information

Original name

Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Aneta POHOŘALÁ (203 Czech Republic, belonging to the institution), Ondřej MIKEŠ (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Zbyněk ŠPLÍCHAL (203 Czech Republic, belonging to the institution) and Hynek PIKHART (203 Czech Republic, belonging to the institution)

Edition

BMC Medical Genetics, ENGLAND, BIOMED CENTRAL LTD, 2017, 1471-2350

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30101 Human genetics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.913

RIV identification code

RIV/00216224:14110/17:00098762

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s12881-017-0454-z

UT WoS

000408145600001

Keywords in English

VDR; SNP; Obesity; Anthropometry; Adiposity; Gene; Vitamin D; Polymorphism; Adiposity measure

Abstract

V originále

Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej MIKEŠ, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK, Zbyněk ŠPLÍCHAL and Hynek PIKHART. Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. BMC Medical Genetics. ENGLAND: BIOMED CENTRAL LTD, 2017, vol. 18, No 90, p. 1-9. ISSN 1471-2350. Available from: https://dx.doi.org/10.1186/s12881-017-0454-z.

@article{1399112,
   author = {Bienertová Vašků, Julie and Zlámal, Filip and Pohořalá, Aneta and Mikeš, Ondřej and Pávková Goldbergová, Monika and Novák, Jan and Šplíchal, Zbyněk and Pikhart, Hynek},
   article_location = {ENGLAND},
   article_number = {90},
   doi = {http://dx.doi.org/10.1186/s12881-017-0454-z},
   keywords = {VDR; SNP; Obesity; Anthropometry; Adiposity; Gene; Vitamin D; Polymorphism; Adiposity measure},
   language = {eng},
   issn = {1471-2350},
   journal = {BMC Medical Genetics},
   title = {Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population},
   volume = {18},
   year = {2017}
}

TY  - JOUR
ID  - 1399112
AU  - Bienertová Vašků, Julie - Zlámal, Filip - Pohořalá, Aneta - Mikeš, Ondřej - Pávková Goldbergová, Monika - Novák, Jan - Šplíchal, Zbyněk - Pikhart, Hynek
PY  - 2017
TI  - Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population
JF  - BMC Medical Genetics
VL  - 18
IS  - 90
SP  - 1-9
EP  - 1-9
PB  - BIOMED CENTRAL LTD
SN  - 14712350
KW  - VDR
KW  - SNP
KW  - Obesity
KW  - Anthropometry
KW  - Adiposity
KW  - Gene
KW  - Vitamin D
KW  - Polymorphism
KW  - Adiposity measure
N2  - Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population. Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms. Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too. Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej MIKEŠ, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK, Zbyněk ŠPLÍCHAL and Hynek PIKHART. Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. \textit{BMC Medical Genetics}. ENGLAND: BIOMED CENTRAL LTD, 2017, vol.~18, No~90, p.~1-9. ISSN~1471-2350. Available from: https://dx.doi.org/10.1186/s12881-017-0454-z.

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