J 2017

Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up

BENDZALA, M., P. SABAKA, M. CAPRNDA, A. KOMORNIKOVA, M. BISAHOVA et. al.

Basic information

Original name

Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up

Authors

BENDZALA, M. (703 Slovakia), P. SABAKA (703 Slovakia), M. CAPRNDA (703 Slovakia), A. KOMORNIKOVA (703 Slovakia), M. BISAHOVA (703 Slovakia), R. BANESZOVA (703 Slovakia), D. PETROVIC (705 Slovenia), R. PROSECKY (203 Czech Republic), L. RODRIGO (724 Spain), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and A. DUKAT (703 Slovakia)

Edition

Wiener klinische Wochenschrift, Vídeň, SPRINGER WIEN, 2017, 0043-5325

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.003

RIV identification code

RIV/00216224:14110/17:00098763

Organization unit

Faculty of Medicine

DOI

UT WoS

000414784300003

Keywords in English

Atherogenic index; HDL; LDL; Risk of mortality; Elderly population

Tags

Tags

International impact, Reviewed
Změněno: 20/3/2018 18:55, Soňa Böhmová

Abstract

V originále

Background The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. Methods We conducted a prospective observational study of patients with arterial hypertension older than 60 years. The concentrations of total cholesterol, LDL, HDL and triacylglycerol were measured at the time of the recruitment and the patients were observed for 10 years. Cox regression analysis was performed to assess the effects of lipoproteins and AIP on survival. Results A total of 500 patients were recruited and 473 of them (226 men, 247 women) either died or successfully completed the 10-year follow-up and were included in the analysis. The AIP was positively associated, while HDL concentration was negatively associated with the risk of all-cause death adjusted for age, smoking habits, statin use, history of diabetes mellitus, myocardial infarction, stroke and peripheral artery occlusive disease (PAOD) in elderly women but not in men. The LDL, total cholesterol, triacylglycerol and non-HDL concentrations were not associated with the risk of death in both sexes. Conclusions The AIP is positively associated with the risk of all-cause death in elderly women with arterial hypertension independent of age, smoking habits, statin therapy and comorbidities.