Atherogenic index of plasma is positively associated with the
risk of all-cause death in elderly women A 10-year follow-up

BENDZALA, M., P. SABAKA, M. CAPRNDA, A. KOMORNIKOVA, M. BISAHOVA, R. BANESZOVA, D. PETROVIC, R. PROSECKY, L. RODRIGO, Peter KRUŽLIAK and A. DUKAT. Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up. Wiener klinische Wochenschrift. Vídeň: SPRINGER WIEN, 2017, vol. 129, 21-22, p. 793-798. ISSN 0043-5325. Available from: https://dx.doi.org/10.1007/s00508-017-1264-1.

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TY  - JOUR
ID  - 1399113
AU  - Bendzala, M. - Sabaka, P. - Caprnda, M. - Komornikova, A. - Bisahova, M. - Baneszova, R. - Petrovic, D. - Prosecky, R. - Rodrigo, L. - Kružliak, Peter - Dukat, A.
PY  - 2017
TI  - Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up
JF  - Wiener klinische Wochenschrift
VL  - 129
IS  - 21-22
SP  - 793-798
EP  - 793-798
PB  - SPRINGER WIEN
SN  - 00435325
KW  - Atherogenic index
KW  - HDL
KW  - LDL
KW  - Risk of mortality
KW  - Elderly population
N2  - Background The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. Methods We conducted a prospective observational study of patients with arterial hypertension older than 60 years. The concentrations of total cholesterol, LDL, HDL and triacylglycerol were measured at the time of the recruitment and the patients were observed for 10 years. Cox regression analysis was performed to assess the effects of lipoproteins and AIP on survival. Results A total of 500 patients were recruited and 473 of them (226 men, 247 women) either died or successfully completed the 10-year follow-up and were included in the analysis. The AIP was positively associated, while HDL concentration was negatively associated with the risk of all-cause death adjusted for age, smoking habits, statin use, history of diabetes mellitus, myocardial infarction, stroke and peripheral artery occlusive disease (PAOD) in elderly women but not in men. The LDL, total cholesterol, triacylglycerol and non-HDL concentrations were not associated with the risk of death in both sexes. Conclusions The AIP is positively associated with the risk of all-cause death in elderly women with arterial hypertension independent of age, smoking habits, statin therapy and comorbidities.
ER  -

Basic information
Original name	Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly women A 10-year follow-up
Authors	BENDZALA, M. (703 Slovakia), P. SABAKA (703 Slovakia), M. CAPRNDA (703 Slovakia), A. KOMORNIKOVA (703 Slovakia), M. BISAHOVA (703 Slovakia), R. BANESZOVA (703 Slovakia), D. PETROVIC (705 Slovenia), R. PROSECKY (203 Czech Republic), L. RODRIGO (724 Spain), Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and A. DUKAT (703 Slovakia).
Edition	Wiener klinische Wochenschrift, Vídeň, SPRINGER WIEN, 2017, 0043-5325.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30218 General and internal medicine
Country of publisher	Austria
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 1.003
RIV identification code	RIV/00216224:14110/17:00098763
Organization unit	Faculty of Medicine
Doi	http://dx.doi.org/10.1007/s00508-017-1264-1
UT WoS	000414784300003
Keywords in English	Atherogenic index; HDL; LDL; Risk of mortality; Elderly population
Tags	EL OK
Tags	International impact, Reviewed
Changed by	Changed by: Soňa Böhmová, učo 232884. Changed: 20/3/2018 18:55.

Abstract

Background The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. Methods We conducted a prospective observational study of patients with arterial hypertension older than 60 years. The concentrations of total cholesterol, LDL, HDL and triacylglycerol were measured at the time of the recruitment and the patients were observed for 10 years. Cox regression analysis was performed to assess the effects of lipoproteins and AIP on survival. Results A total of 500 patients were recruited and 473 of them (226 men, 247 women) either died or successfully completed the 10-year follow-up and were included in the analysis. The AIP was positively associated, while HDL concentration was negatively associated with the risk of all-cause death adjusted for age, smoking habits, statin use, history of diabetes mellitus, myocardial infarction, stroke and peripheral artery occlusive disease (PAOD) in elderly women but not in men. The LDL, total cholesterol, triacylglycerol and non-HDL concentrations were not associated with the risk of death in both sexes. Conclusions The AIP is positively associated with the risk of all-cause death in elderly women with arterial hypertension independent of age, smoking habits, statin therapy and comorbidities.

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Atherogenic index of plasma is positively associated with the risk of all-cause death in elderly ...

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