Disruption in Cerebellar and Basal Ganglia Networks During a
Visuospatial Task in Cervical Dystonia

J 2017

Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

FILIP, Pavel, C. GALLEA, S. LEHERICY, E. BERTASI, T. POPA et. al.

Basic information

Original name

Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

Authors

FILIP, Pavel (703 Slovakia, guarantor, belonging to the institution), C. GALLEA (250 France), S. LEHERICY (250 France), E. BERTASI (250 France), T. POPA (250 France), Radek MAREČEK (203 Czech Republic, belonging to the institution), O.V. LUNGU (124 Canada), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, belonging to the institution)

Edition

Movement Disorders, HOBOKEN, WILEY, 2017, 0885-3185

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 8.324

RIV identification code

RIV/00216224:14110/17:00098773

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/mds.26930

UT WoS

000401936200018

Keywords in English

cervical dystonia; cerebellum; basal ganglia; fMRI; functional connectivity

Abstract

V originále

Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

FILIP, Pavel, C. GALLEA, S. LEHERICY, E. BERTASI, T. POPA, Radek MAREČEK, O.V. LUNGU, Tomáš KAŠPÁREK, Jiří VANÍČEK and Martin BAREŠ. Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia. Movement Disorders. HOBOKEN: WILEY, 2017, vol. 32, No 5, p. 757-768. ISSN 0885-3185. Available from: https://dx.doi.org/10.1002/mds.26930.

@article{1399126,
   author = {Filip, Pavel and Gallea, C. and Lehericy, S. and Bertasi, E. and Popa, T. and Mareček, Radek and Lungu, O.V. and Kašpárek, Tomáš and Vaníček, Jiří and Bareš, Martin},
   article_location = {HOBOKEN},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/mds.26930},
   keywords = {cervical dystonia; cerebellum; basal ganglia; fMRI; functional connectivity},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1399126
AU  - Filip, Pavel - Gallea, C. - Lehericy, S. - Bertasi, E. - Popa, T. - Mareček, Radek - Lungu, O.V. - Kašpárek, Tomáš - Vaníček, Jiří - Bareš, Martin
PY  - 2017
TI  - Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia
JF  - Movement Disorders
VL  - 32
IS  - 5
SP  - 757-768
EP  - 757-768
PB  - WILEY
SN  - 08853185
KW  - cervical dystonia
KW  - cerebellum
KW  - basal ganglia
KW  - fMRI
KW  - functional connectivity
N2  - Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society
ER  -

FILIP, Pavel, C. GALLEA, S. LEHERICY, E. BERTASI, T. POPA, Radek MAREČEK, O.V. LUNGU, Tomáš KAŠPÁREK, Jiří VANÍČEK and Martin BAREŠ. Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia. \textit{Movement Disorders}. HOBOKEN: WILEY, 2017, vol.~32, No~5, p.~757-768. ISSN~0885-3185. Available from: https://dx.doi.org/10.1002/mds.26930.

Detailed Information on Publication Record