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@article{1399126, author = {Filip, Pavel and Gallea, C. and Lehericy, S. and Bertasi, E. and Popa, T. and Mareček, Radek and Lungu, O.V. and Kašpárek, Tomáš and Vaníček, Jiří and Bareš, Martin}, article_location = {HOBOKEN}, article_number = {5}, doi = {http://dx.doi.org/10.1002/mds.26930}, keywords = {cervical dystonia; cerebellum; basal ganglia; fMRI; functional connectivity}, language = {eng}, issn = {0885-3185}, journal = {Movement Disorders}, title = {Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia}, volume = {32}, year = {2017} }
TY - JOUR ID - 1399126 AU - Filip, Pavel - Gallea, C. - Lehericy, S. - Bertasi, E. - Popa, T. - Mareček, Radek - Lungu, O.V. - Kašpárek, Tomáš - Vaníček, Jiří - Bareš, Martin PY - 2017 TI - Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia JF - Movement Disorders VL - 32 IS - 5 SP - 757-768 EP - 757-768 PB - WILEY SN - 08853185 KW - cervical dystonia KW - cerebellum KW - basal ganglia KW - fMRI KW - functional connectivity N2 - Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society ER -
FILIP, Pavel, C. GALLEA, S. LEHERICY, E. BERTASI, T. POPA, Radek MAREČEK, O.V. LUNGU, Tomáš KAŠPÁREK, Jiří VANÍČEK and Martin BAREŠ. Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia. \textit{Movement Disorders}. HOBOKEN: WILEY, 2017, vol.~32, No~5, p.~757-768. ISSN~0885-3185. Available from: https://dx.doi.org/10.1002/mds.26930.
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