Progress in human pluripotent stem cell-based modeling systems for neurological diseases

HŘÍBKOVÁ, Hana, Jana ZELINKOVÁ and Yuh-Man WADELEY. Progress in human pluripotent stem cell-based modeling systems for neurological diseases. Neurogenesis. Oxford: Taylor & Francis, vol. 4, No 1, p. "e1324258-1"-"e1324258-6", 6 pp. ISSN 2326-2133. doi:10.1080/23262133.2017.1324258. 2017.

Basic information

• Original name: Progress in human pluripotent stem cell-based modeling systems for neurological diseases
• Authors: HŘÍBKOVÁ, Hana (203 Czech Republic, belonging to the institution), Jana ZELINKOVÁ (203 Czech Republic, belonging to the institution) and Yuh-Man WADELEY (826 United Kingdom of Great Britain and Northern Ireland, guarantor, belonging to the institution).
• Edition: Neurogenesis, Oxford, Taylor & Francis, 2017, 2326-2133.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/17:00098812
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1080/23262133.2017.1324258
• Keywords in English: 3-D culturing; cell fate decision; hPSC-based disease modeling; human pluripotent stem cell; neural developmental modeling
• Tags: EL OK
• Tags: Reviewed

Abstract

Human pluripotent stem cell (hPSC)-based modeling offers the potential for studying human diseases using human systems. An increasing number of studies in numerous fields demonstrate that hPSC-based disease systems capture disease specific pathophysiology occurring in vivo. A widespread deployment of hPSC systems is foreseeable. Even the field of psychiatric disorders (for example, schizophrenia and autism), which lags behind due to complex underlying causes, such as the inaccessibility of brain cells for assessments and the absence of reliable models, has been embracing the hPSC-based disease system. However, despite hPSCs holding great potential, it is imperative to validate how faithful hPSC-based neural developmental modeling is in recapitulating the developmental process in vivo. Our recent study demonstrated that the hPSC-based system mimicked the process of neural development and the system reserved neural stem cell (NSC) niches similar to those residing in the ventricular region of the cortex. In this article, we will first comment on an array of factors that affect hPSC-based neural differentiation and summarize the intricate regulatory signaling pathways that regionalize neuronal cell types. Finally, we review successful studies in brain-related diseases using hPSC-based modeling with 3-D systems.