Comparing Clinical Characteristics and Outcomes of Young-onset
and Late-onset Colorectal Cancer: An International
Collaborative Study

J 2017

Comparing Clinical Characteristics and Outcomes of Young-onset and Late-onset Colorectal Cancer: An International Collaborative Study

RHO, Y.S., M. GILABERT, K. POLOM, A. ALADASHVILI, K. KOPECKOVA et. al.

Basic information

Original name

Comparing Clinical Characteristics and Outcomes of Young-onset and Late-onset Colorectal Cancer: An International Collaborative Study

Authors

RHO, Y.S. (124 Canada), M. GILABERT (250 France), K. POLOM (380 Italy), A. ALADASHVILI (268 Georgia), K. KOPECKOVA (203 Czech Republic), V. MEGDANOVA (100 Bulgaria), N. COLEMAN (372 Ireland), M. GREALLY (372 Ireland), D. MARRELLI (380 Italy), F. ROVIELLO (380 Italy), R. MCDERMOTT (100 Bulgaria), V. PETROVA (100 Bulgaria), Z. MIHAYLOVA (100 Bulgaria), Zbyněk BORTLÍČEK (203 Czech Republic, guarantor, belonging to the institution), J. PRAUSOVA (203 Czech Republic), G. BATIST (124 Canada), L. AZOULAY (124 Canada) and P. KAVAN (124 Canada)

Edition

CLINICAL COLORECTAL CANCER, DALLAS, CIG MEDIA GROUP, LP, 2017, 1533-0028

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.861

RIV identification code

RIV/00216224:14110/17:00098838

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.clcc.2017.03.008

UT WoS

000416182900011

Keywords in English

Adolescent and young adults; Metastatic colorectal cancer; Real world; Treatment pattern; Young-onset CRC

Abstract

V originále

Colorectal cancer in young patients is often diagnosed late, at advanced stages. These patients have more resistant and aggressive disease, despite similar clinical treatment patterns compared with those with late-onset disease. Background: Compared with the general population, the incidence of young-onset (YO) colorectal cancer (CRC) is increasing. However, a significant knowledge gap exists in the clinical characteristics, treatment patterns, and outcomes for these patients. Materials and Methods: Six international tertiary cancer centers conducted a retrospective study. Patients with YO CRC (aged 18-44 years) and LO CRC (aged > 44 years) diagnosed with histologically proven colorectal adenocarcinoma from June 2003 to June 2014 were enrolled. Patients were randomly chosen from each center's database, and the patient demographics and treatment information were collected. The data were then centralized, and the final analysis was performed at a single institution. Cox proportional hazards models were used to estimate the crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for progression-free survival and mortality, and YO was compared with LO. Site-specific HRs were pooled using a random-effects meta-analysis. Results: Overall, 498 patients, including 224 with YO (129 men; mean age, 37 +/- 5.5 years) and 274 with LO (167 men; mean age, 64.8 +/- 9.5 years) CRC, were included. At the diagnosis, 137 patients (61.2%) and 122 patients (44.5%) with YO and LO CRC had metastatic disease, respectively. For both cohorts, the 3 most common presenting symptoms were pain, hematochezia, and weight loss. Surgery was performed in 141 YO (63.0%) and 219 LO (79.9%) patients. The longitudinal noncurative treatment patterns were similar, but more biologic therapy was used for these YO patients. The pooled progression-free survival analysis results for first-line noncurative treatment favored LO (HR, 1.96; 95% CI, 1.04-3.68). The mortality analysis showed no significant differences between the 2 groups (YO: HR, 1.53; 95% CI, 0.91-2.58). Conclusion: Despite similar treatment patterns and survival outcomes, YO disease might be clinically more aggressive. (C) 2017 Elsevier Inc. All rights reserved.

Citovat

RHO, Y.S., M. GILABERT, K. POLOM, A. ALADASHVILI, K. KOPECKOVA, V. MEGDANOVA, N. COLEMAN, M. GREALLY, D. MARRELLI, F. ROVIELLO, R. MCDERMOTT, V. PETROVA, Z. MIHAYLOVA, Zbyněk BORTLÍČEK, J. PRAUSOVA, G. BATIST, L. AZOULAY and P. KAVAN. Comparing Clinical Characteristics and Outcomes of Young-onset and Late-onset Colorectal Cancer: An International Collaborative Study. CLINICAL COLORECTAL CANCER. DALLAS: CIG MEDIA GROUP, LP, 2017, vol. 16, No 4, p. 334-342. ISSN 1533-0028. Available from: https://dx.doi.org/10.1016/j.clcc.2017.03.008.

@article{1399363,
   author = {Rho, Y.S. and Gilabert, M. and Polom, K. and Aladashvili, A. and Kopeckova, K. and Megdanova, V. and Coleman, N. and Greally, M. and Marrelli, D. and Roviello, F. and McDermott, R. and Petrova, V. and Mihaylova, Z. and Bortlíček, Zbyněk and Prausova, J. and Batist, G. and Azoulay, L. and Kavan, P.},
   article_location = {DALLAS},
   article_number = {4},
   doi = {http://dx.doi.org/10.1016/j.clcc.2017.03.008},
   keywords = {Adolescent and young adults; Metastatic colorectal cancer; Real world; Treatment pattern; Young-onset CRC},
   language = {eng},
   issn = {1533-0028},
   journal = {CLINICAL COLORECTAL CANCER},
   title = {Comparing Clinical Characteristics and Outcomes of Young-onset and Late-onset Colorectal Cancer: An International Collaborative Study},
   volume = {16},
   year = {2017}
}

TY  - JOUR
ID  - 1399363
AU  - Rho, Y.S. - Gilabert, M. - Polom, K. - Aladashvili, A. - Kopeckova, K. - Megdanova, V. - Coleman, N. - Greally, M. - Marrelli, D. - Roviello, F. - McDermott, R. - Petrova, V. - Mihaylova, Z. - Bortlíček, Zbyněk - Prausova, J. - Batist, G. - Azoulay, L. - Kavan, P.
PY  - 2017
TI  - Comparing Clinical Characteristics and Outcomes of Young-onset and Late-onset Colorectal Cancer: An International Collaborative Study
JF  - CLINICAL COLORECTAL CANCER
VL  - 16
IS  - 4
SP  - 334-342
EP  - 334-342
PB  - CIG MEDIA GROUP, LP
SN  - 15330028
KW  - Adolescent and young adults
KW  - Metastatic colorectal cancer
KW  - Real world
KW  - Treatment pattern
KW  - Young-onset CRC
N2  - Colorectal cancer in young patients is often diagnosed late, at advanced stages. These patients have more resistant and aggressive disease, despite similar clinical treatment patterns compared with those with late-onset disease. Background: Compared with the general population, the incidence of young-onset (YO) colorectal cancer (CRC) is increasing. However, a significant knowledge gap exists in the clinical characteristics, treatment patterns, and outcomes for these patients. Materials and Methods: Six international tertiary cancer centers conducted a retrospective study. Patients with YO CRC (aged 18-44 years) and LO CRC (aged > 44 years) diagnosed with histologically proven colorectal adenocarcinoma from June 2003 to June 2014 were enrolled. Patients were randomly chosen from each center's database, and the patient demographics and treatment information were collected. The data were then centralized, and the final analysis was performed at a single institution. Cox proportional hazards models were used to estimate the crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for progression-free survival and mortality, and YO was compared with LO. Site-specific HRs were pooled using a random-effects meta-analysis. Results: Overall, 498 patients, including 224 with YO (129 men; mean age, 37 +/- 5.5 years) and 274 with LO (167 men; mean age, 64.8 +/- 9.5 years) CRC, were included. At the diagnosis, 137 patients (61.2%) and 122 patients (44.5%) with YO and LO CRC had metastatic disease, respectively. For both cohorts, the 3 most common presenting symptoms were pain, hematochezia, and weight loss. Surgery was performed in 141 YO (63.0%) and 219 LO (79.9%) patients. The longitudinal noncurative treatment patterns were similar, but more biologic therapy was used for these YO patients. The pooled progression-free survival analysis results for first-line noncurative treatment favored LO (HR, 1.96; 95% CI, 1.04-3.68). The mortality analysis showed no significant differences between the 2 groups (YO: HR, 1.53; 95% CI, 0.91-2.58). Conclusion: Despite similar treatment patterns and survival outcomes, YO disease might be clinically more aggressive. (C) 2017 Elsevier Inc. All rights reserved.
ER  -

RHO, Y.S., M. GILABERT, K. POLOM, A. ALADASHVILI, K. KOPECKOVA, V. MEGDANOVA, N. COLEMAN, M. GREALLY, D. MARRELLI, F. ROVIELLO, R. MCDERMOTT, V. PETROVA, Z. MIHAYLOVA, Zbyněk BORTLÍČEK, J. PRAUSOVA, G. BATIST, L. AZOULAY and P. KAVAN. Comparing Clinical Characteristics and Outcomes of Young-onset and Late-onset Colorectal Cancer: An International Collaborative Study. \textit{CLINICAL COLORECTAL CANCER}. DALLAS: CIG MEDIA GROUP, LP, 2017, vol.~16, No~4, p.~334-342. ISSN~1533-0028. Available from: https://dx.doi.org/10.1016/j.clcc.2017.03.008.

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