Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients

JAROŠOVÁ, Marie, M. HRUBA, Alexandra OLTOVÁ, Karla PLEVOVÁ, L. KRUZOVA, E. KRIEGOVA, R. FILLEROVA, Eva KORIŤÁKOVÁ, Michael DOUBEK, D. LYSAK, V. PROCHAZKA, Marek MRÁZ, K. INDRAK and T. PAPAJIK. Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients. American Journal of Hematology. NJ 07030-577 United States: John Wiley & Sons, 2017, vol. 92, No 10, p. "E604"-"E607", 5 pp. ISSN 0361-8609. Available from: https://dx.doi.org/10.1002/ajh.24852.

Basic information

• Original name: Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients
• Authors: JAROŠOVÁ, Marie (203 Czech Republic, guarantor, belonging to the institution), M. HRUBA (203 Czech Republic), Alexandra OLTOVÁ (203 Czech Republic, belonging to the institution), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), L. KRUZOVA (203 Czech Republic), E. KRIEGOVA (203 Czech Republic), R. FILLEROVA (203 Czech Republic), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution), D. LYSAK (203 Czech Republic), V. PROCHAZKA (203 Czech Republic), Marek MRÁZ (203 Czech Republic, belonging to the institution), K. INDRAK (203 Czech Republic) and T. PAPAJIK (203 Czech Republic).
• Edition: American Journal of Hematology, NJ 07030-577 United States, John Wiley & Sons, 2017, 0361-8609.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30205 Hematology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 5.303
• RIV identification code: RIV/00216224:14110/17:00095685
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1002/ajh.24852
• UT WoS: 000409203200010
• Keywords in English: Chromosome 6q
• Tags: EL OK, podil
• Tags: International impact, Reviewed

Abstract

Detection of genetic changes has improved the current risk stratification in chronic lymphocytic leukemia (CLL).1,2 Among the known recurrent chromosomal abnormalities,1 6q deletion is less frequent and controversy surrounding its prognostic significance still remains.

Links

• NV15-31834A, research and development project: Name: Vliv selekce genomických poškození na průběh chronické lymfocytární leukémie
• NV16-29622A, research and development project: Name: VLIV TERAPEUTICKÉ INHIBICE BCR SIGNALIZACE NA GENOVOU EXPRESI U B BUNĚČNÝCH MALIGNIT A JEJÍ PROGNOSTICKÝ A PREDIKTIVNÍ VÝZNAM