Next-generation sequencing in chronic lymphocytic leukemia:
recent findings and new horizons

J 2017

Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons

RODRIGUEZ-VICENTE, A.E., Vasileios BIKOS, V. HERNANDEZ-SANCHEZ, Jitka MALČÍKOVÁ, J.M. HERNANDEZ-RIVAS et. al.

Basic information

Original name

Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons

Authors

RODRIGUEZ-VICENTE, A.E. (724 Spain), Vasileios BIKOS (300 Greece, belonging to the institution), V. HERNANDEZ-SANCHEZ (724 Spain), Jitka MALČÍKOVÁ (203 Czech Republic, belonging to the institution), J.M. HERNANDEZ-RIVAS (724 Spain) and Šárka POSPÍŠILOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Oncotarget, Albany, Impact Journals, 2017, 1949-2553

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.168 in 2016

RIV identification code

RIV/00216224:14110/17:00095686

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.18632/oncotarget.19525

UT WoS

000411153300165

Keywords in English

chronic lymphocytic leukemia; next-generation sequencing; clonal evolution; immunogenetics; CLL prognosis

Abstract

V originále

The rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next-generation sequencing has revealed an immense degree of both intra- and inter-tumor heterogeneity and enabled us to describe marked clonal evolution. Advances in immunogenetics may be implemented to detect minimal residual disease more sensitively and to track clonal B cell populations, their dynamics and molecular characteristics. The interpretation of these aspects is indispensable to thoroughly examine the genetic background of chronic lymphocytic leukemia. We review and discuss the recent results provided by the different next-generation sequencing techniques used in studying the chronic lymphocytic leukemia genome, as well as future perspectives in the methodologies and applications.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV15-30015A, research and development project

Name: Analýza klonální heterogenity chronické lymfocytární leukemie pomoci sekvenování nové generace genu pro B-buněčný receptor. Národní studie.

NV15-31834A, research and development project

Name: Vliv selekce genomických poškození na průběh chronické lymfocytární leukémie

NV16-29447A, research and development project

Name: Vyhledávání mutací predisponujících k familiárním hematologickým a onkologickým onemocněním

7E13008, research and development project

Name: Next Generation Sequencing Platform for Targeted Personalized Therapy of Leukemia (Acronym: NGS-PTL)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

RODRIGUEZ-VICENTE, A.E., Vasileios BIKOS, V. HERNANDEZ-SANCHEZ, Jitka MALČÍKOVÁ, J.M. HERNANDEZ-RIVAS and Šárka POSPÍŠILOVÁ. Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons. Oncotarget. Albany: Impact Journals, 2017, vol. 8, No 41, p. 71234-71248. ISSN 1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.19525.

@article{1400043,
   author = {RodriguezandVicente, A.E. and Bikos, Vasileios and HernandezandSanchez, V. and Malčíková, Jitka and HernandezandRivas, J.M. and Pospíšilová, Šárka},
   article_location = {Albany},
   article_number = {41},
   doi = {http://dx.doi.org/10.18632/oncotarget.19525},
   keywords = {chronic lymphocytic leukemia; next-generation sequencing; clonal evolution; immunogenetics; CLL prognosis},
   language = {eng},
   issn = {1949-2553},
   journal = {Oncotarget},
   title = {Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons},
   volume = {8},
   year = {2017}
}

TY  - JOUR
ID  - 1400043
AU  - Rodriguez-Vicente, A.E. - Bikos, Vasileios - Hernandez-Sanchez, V. - Malčíková, Jitka - Hernandez-Rivas, J.M. - Pospíšilová, Šárka
PY  - 2017
TI  - Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
JF  - Oncotarget
VL  - 8
IS  - 41
SP  - 71234-71248
EP  - 71234-71248
PB  - Impact Journals
SN  - 19492553
KW  - chronic lymphocytic leukemia
KW  - next-generation sequencing
KW  - clonal evolution
KW  - immunogenetics
KW  - CLL prognosis
N2  - The rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next-generation sequencing has revealed an immense degree of both intra- and inter-tumor heterogeneity and enabled us to describe marked clonal evolution. Advances in immunogenetics may be implemented to detect minimal residual disease more sensitively and to track clonal B cell populations, their dynamics and molecular characteristics. The interpretation of these aspects is indispensable to thoroughly examine the genetic background of chronic lymphocytic leukemia. We review and discuss the recent results provided by the different next-generation sequencing techniques used in studying the chronic lymphocytic leukemia genome, as well as future perspectives in the methodologies and applications.
ER  -

RODRIGUEZ-VICENTE, A.E., Vasileios BIKOS, V. HERNANDEZ-SANCHEZ, Jitka MALČÍKOVÁ, J.M. HERNANDEZ-RIVAS and Šárka POSPÍŠILOVÁ. Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons. \textit{Oncotarget}. Albany: Impact Journals, 2017, vol.~8, No~41, p.~71234-71248. ISSN~1949-2553. Available from: https://dx.doi.org/10.18632/oncotarget.19525.

Detailed Information on Publication Record