Atypical handedness in mesial temporal lobe epilepsy

J 2017

Atypical handedness in mesial temporal lobe epilepsy

DOLEŽALOVÁ, Irena, S. SCHACHTER, Jan CHRASTINA, Jan HEMZA, Markéta HERMANOVÁ et. al.

Basic information

Original name

Atypical handedness in mesial temporal lobe epilepsy

Authors

DOLEŽALOVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), S. SCHACHTER (840 United States of America), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Jan HEMZA (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution), Marta PAŽOURKOVÁ (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)

Edition

EPILEPSY & BEHAVIOR, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017, 1525-5050

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.600

RIV identification code

RIV/00216224:14110/17:00099039

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.yebeh.2017.01.034

UT WoS

000406321300014

Keywords in English

Mesial temporal lobe epilepsy; Handedness; Left-handed; Right-handed; Age at epilepsy onset; Atypical dominance

Abstract

V originále

Objective: The main aim of our study was to investigate the handedness of patients with mesial temporal lobe epilepsy (MTLE). We also sought to identify clinical variables that correlated with left-handedness in this population. Methods: Handedness (laterality quotient) was assessed in 73 consecutive patients with MTLE associated with unilateral hippocampal sclerosis (HS) using the Edinburgh Handedness Inventory. Associations between rightand left-handedness and clinical variables were investigated. Results: We found that 54 (74.0%) patients were right-handed, and 19 (26%) patients were left-handed. There were 15 (36.6%) left-handed patients with left-sided seizure onset compared to 4 (12.5%) left-handed patients with right-sided seizure onset (p = 0.030). Among patients with left-sided MTLE, age at epilepsy onset was significantly correlated with handedness (8 years of age [median; min-max 0.5-17] in left-handers versus 15 years of age [median; min-max 3-30] in right-handers (p < 0.001). Conclusions: Left-sided MTLE is associatedwith atypical handedness, especiallywhen seizure onset occurs during an active period of brain development, suggesting a bi-hemispheric neuroplastic process for establishing motor dominance in patients with early-onset left-sided MTLE. (C) 2017 Elsevier Inc. All rights reserved.

Citovat

DOLEŽALOVÁ, Irena, S. SCHACHTER, Jan CHRASTINA, Jan HEMZA, Markéta HERMANOVÁ, Ivan REKTOR, Marta PAŽOURKOVÁ and Milan BRÁZDIL. Atypical handedness in mesial temporal lobe epilepsy. EPILEPSY & BEHAVIOR. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017, vol. 72, JUL 2017, p. 78-81. ISSN 1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2017.01.034.

@article{1400988,
   author = {Doležalová, Irena and Schachter, S. and Chrastina, Jan and Hemza, Jan and Hermanová, Markéta and Rektor, Ivan and Pažourková, Marta and Brázdil, Milan},
   article_location = {SAN DIEGO},
   article_number = {JUL 2017},
   doi = {http://dx.doi.org/10.1016/j.yebeh.2017.01.034},
   keywords = {Mesial temporal lobe epilepsy; Handedness; Left-handed; Right-handed; Age at epilepsy onset; Atypical dominance},
   language = {eng},
   issn = {1525-5050},
   journal = {EPILEPSY & BEHAVIOR},
   title = {Atypical handedness in mesial temporal lobe epilepsy},
   volume = {72},
   year = {2017}
}

TY  - JOUR
ID  - 1400988
AU  - Doležalová, Irena - Schachter, S. - Chrastina, Jan - Hemza, Jan - Hermanová, Markéta - Rektor, Ivan - Pažourková, Marta - Brázdil, Milan
PY  - 2017
TI  - Atypical handedness in mesial temporal lobe epilepsy
JF  - EPILEPSY & BEHAVIOR
VL  - 72
IS  - JUL 2017
SP  - 78-81
EP  - 78-81
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 15255050
KW  - Mesial temporal lobe epilepsy
KW  - Handedness
KW  - Left-handed
KW  - Right-handed
KW  - Age at epilepsy onset
KW  - Atypical dominance
N2  - Objective: The main aim of our study was to investigate the handedness of patients with mesial temporal lobe epilepsy (MTLE). We also sought to identify clinical variables that correlated with left-handedness in this population. Methods: Handedness (laterality quotient) was assessed in 73 consecutive patients with MTLE associated with unilateral hippocampal sclerosis (HS) using the Edinburgh Handedness Inventory. Associations between rightand left-handedness and clinical variables were investigated. Results: We found that 54 (74.0%) patients were right-handed, and 19 (26%) patients were left-handed. There were 15 (36.6%) left-handed patients with left-sided seizure onset compared to 4 (12.5%) left-handed patients with right-sided seizure onset (p = 0.030). Among patients with left-sided MTLE, age at epilepsy onset was significantly correlated with handedness (8 years of age [median; min-max 0.5-17] in left-handers versus 15 years of age [median; min-max 3-30] in right-handers (p < 0.001). Conclusions: Left-sided MTLE is associatedwith atypical handedness, especiallywhen seizure onset occurs during an active period of brain development, suggesting a bi-hemispheric neuroplastic process for establishing motor dominance in patients with early-onset left-sided MTLE. (C) 2017 Elsevier Inc. All rights reserved.
ER  -

DOLEŽALOVÁ, Irena, S. SCHACHTER, Jan CHRASTINA, Jan HEMZA, Markéta HERMANOVÁ, Ivan REKTOR, Marta PAŽOURKOVÁ and Milan BRÁZDIL. Atypical handedness in mesial temporal lobe epilepsy. \textit{EPILEPSY \&{}amp; BEHAVIOR}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017, vol.~72, JUL 2017, p.~78-81. ISSN~1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2017.01.034.

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