Very High-Frequency Oscillations: Novel Biomarkers of the
Epileptogenic Zone

J 2017

Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone

BRÁZDIL, Milan; Martin PAIL; J. HALAMEK; F. PLESINGER; J. CIMBALNIK et al.

Základní údaje

Originální název

Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone

Autoři

BRÁZDIL, Milan; Martin PAIL; J. HALAMEK; F. PLESINGER; J. CIMBALNIK; Robert ROMAN ; P. KLIMES; Pavel DANIEL ; Jan CHRASTINA; Eva BRICHTOVÁ; Ivan REKTOR; G.A. WORRELL a P. JURAK

Vydání

Annals of neurology, Hoboken, John Wiley & Sons, 2017, 0364-5134

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 10.250

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/17:00099070

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Biomarkers of the Epileptogenic Zone

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 12. 2018 12:49, Soňa Böhmová

Anotace

V originále

Objective: In the present study, we aimed to investigate depth electroencephalographic (EEG) recordings in a large cohort of patients with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) between 500Hz and 2kHz. We hypothesized that interictal VHFOs are more specific biomarkers for epileptogenic zone compared to traditional HFOs. Methods: Forty patients with focal epilepsy who underwent presurgical stereo-EEG (SEEG) were included in the study. SEEG data were recorded with a sampling rate of 25kHz, and a 30-minute resting period was analyzed for each patient. Ten patients met selected criteria for analyses of correlations with surgical outcome: detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs; resective surgery; and at least 1 year of postoperative follow-up. Using power envelope computation and visual inspection of power distribution matrixes, electrode contacts with HFOs and VHFOs were detected and analyzed. Results: Interictal very fast ripples (VFRs; 500-1,000Hz) were detected in 23 of 40 patients and ultrafast ripples (UFRs; 1,000-2,000Hz) in almost half of investigated subjects (n=19). VFRs and UFRs were observed only in patients with temporal lobe epilepsy and were recorded exclusively from mesiotemporal structures. The UFRs were more spatially restricted in the brain than lower-frequency HFOs. When compared to R oscillations, significantly better outcomes were observed in patients with a higher percentage of removed contacts containing FRs, VFRs, and UFRs. Interpretation: Interictal VHFOs are relatively frequent abnormal phenomena in patients with epilepsy, and appear to be more specific biomarkers for epileptogenic zone when compared to traditional HFOs.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

ROZV/25/LF/2017, interní kód MU

Název: LF - Příspěvek na IP 2017

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek na IP 2017, Interní rozvojové projekty

Citovat

BRÁZDIL, Milan; Martin PAIL; J. HALAMEK; F. PLESINGER; J. CIMBALNIK; Robert ROMAN; P. KLIMES; Pavel DANIEL; Jan CHRASTINA; Eva BRICHTOVÁ; Ivan REKTOR; G.A. WORRELL a P. JURAK. Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone. Annals of neurology. Hoboken: John Wiley & Sons, 2017, roč. 82, č. 2, s. 299-310. ISSN 0364-5134. Dostupné z: https://doi.org/10.1002/ana.25006.

@article{1401237,
   author = {Brázdil, Milan and Pail, Martin and Halamek, J. and Plesinger, F. and Cimbalnik, J. and Roman, Robert and Klimes, P. and Daniel, Pavel and Chrastina, Jan and Brichtová, Eva and Rektor, Ivan and Worrell, G.A. and Jurak, P.},
   article_location = {Hoboken},
   article_number = {2},
   doi = {https://doi.org/10.1002/ana.25006},
   keywords = {Biomarkers of the Epileptogenic Zone},
   language = {eng},
   issn = {0364-5134},
   journal = {Annals of neurology},
   title = {Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone},
   volume = {82},
   year = {2017}
}

TY  - JOUR
ID  - 1401237
AU  - Brázdil, Milan - Pail, Martin - Halamek, J. - Plesinger, F. - Cimbalnik, J. - Roman, Robert - Klimes, P. - Daniel, Pavel - Chrastina, Jan - Brichtová, Eva - Rektor, Ivan - Worrell, G.A. - Jurak, P.
PY  - 2017
TI  - Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone
JF  - Annals of neurology
VL  - 82
IS  - 2
SP  - 299-310
EP  - 299-310
PB  - John Wiley & Sons
SN  - 03645134
KW  - Biomarkers of the Epileptogenic Zone
N2  - Objective: In the present study, we aimed to investigate depth electroencephalographic (EEG) recordings in a large cohort of patients with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) between 500Hz and 2kHz. We hypothesized that interictal VHFOs are more specific biomarkers for epileptogenic zone compared to traditional HFOs. Methods: Forty patients with focal epilepsy who underwent presurgical stereo-EEG (SEEG) were included in the study. SEEG data were recorded with a sampling rate of 25kHz, and a 30-minute resting period was analyzed for each patient. Ten patients met selected criteria for analyses of correlations with surgical outcome: detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs; resective surgery; and at least 1 year of postoperative follow-up. Using power envelope computation and visual inspection of power distribution matrixes, electrode contacts with HFOs and VHFOs were detected and analyzed. Results: Interictal very fast ripples (VFRs; 500-1,000Hz) were detected in 23 of 40 patients and ultrafast ripples (UFRs; 1,000-2,000Hz) in almost half of investigated subjects (n=19). VFRs and UFRs were observed only in patients with temporal lobe epilepsy and were recorded exclusively from mesiotemporal structures. The UFRs were more spatially restricted in the brain than lower-frequency HFOs. When compared to R oscillations, significantly better outcomes were observed in patients with a higher percentage of removed contacts containing FRs, VFRs, and UFRs. Interpretation: Interictal VHFOs are relatively frequent abnormal phenomena in patients with epilepsy, and appear to be more specific biomarkers for epileptogenic zone when compared to traditional HFOs.
ER  -

BRÁZDIL, Milan; Martin PAIL; J. HALAMEK; F. PLESINGER; J. CIMBALNIK; Robert ROMAN; P. KLIMES; Pavel DANIEL; Jan CHRASTINA; Eva BRICHTOVÁ; Ivan REKTOR; G.A. WORRELL a P. JURAK. Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone. \textit{Annals of neurology}. Hoboken: John Wiley \&{} Sons, 2017, roč.~82, č.~2, s.~299-310. ISSN~0364-5134. Dostupné z: https://doi.org/10.1002/ana.25006.

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