Very High-Frequency Oscillations: Novel Biomarkers of the
Epileptogenic Zone

J 2017

Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone

BRÁZDIL, Milan, Martin PAIL, J. HALAMEK, F. PLESINGER, J. CIMBALNIK et. al.

Basic information

Original name

Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone

Authors

BRÁZDIL, Milan (203 Czech Republic, guarantor, belonging to the institution), Martin PAIL (203 Czech Republic, belonging to the institution), J. HALAMEK (203 Czech Republic), F. PLESINGER (203 Czech Republic), J. CIMBALNIK (203 Czech Republic), Robert ROMAN (203 Czech Republic, belonging to the institution), P. KLIMES (203 Czech Republic), Pavel DANIEL (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Eva BRICHTOVÁ (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution), G.A. WORRELL (203 Czech Republic) and P. JURAK (203 Czech Republic)

Edition

Annals of neurology, Hoboken, John Wiley & Sons, 2017, 0364-5134

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 10.250

RIV identification code

RIV/00216224:14110/17:00099070

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/ana.25006

UT WoS

000408080300014

Keywords in English

Biomarkers of the Epileptogenic Zone

Abstract

V originále

Objective: In the present study, we aimed to investigate depth electroencephalographic (EEG) recordings in a large cohort of patients with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) between 500Hz and 2kHz. We hypothesized that interictal VHFOs are more specific biomarkers for epileptogenic zone compared to traditional HFOs. Methods: Forty patients with focal epilepsy who underwent presurgical stereo-EEG (SEEG) were included in the study. SEEG data were recorded with a sampling rate of 25kHz, and a 30-minute resting period was analyzed for each patient. Ten patients met selected criteria for analyses of correlations with surgical outcome: detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs; resective surgery; and at least 1 year of postoperative follow-up. Using power envelope computation and visual inspection of power distribution matrixes, electrode contacts with HFOs and VHFOs were detected and analyzed. Results: Interictal very fast ripples (VFRs; 500-1,000Hz) were detected in 23 of 40 patients and ultrafast ripples (UFRs; 1,000-2,000Hz) in almost half of investigated subjects (n=19). VFRs and UFRs were observed only in patients with temporal lobe epilepsy and were recorded exclusively from mesiotemporal structures. The UFRs were more spatially restricted in the brain than lower-frequency HFOs. When compared to R oscillations, significantly better outcomes were observed in patients with a higher percentage of removed contacts containing FRs, VFRs, and UFRs. Interpretation: Interictal VHFOs are relatively frequent abnormal phenomena in patients with epilepsy, and appear to be more specific biomarkers for epileptogenic zone when compared to traditional HFOs.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

ROZV/25/LF/2017, interní kód MU

Name: LF - Příspěvek na IP 2017

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects

Citovat

BRÁZDIL, Milan, Martin PAIL, J. HALAMEK, F. PLESINGER, J. CIMBALNIK, Robert ROMAN, P. KLIMES, Pavel DANIEL, Jan CHRASTINA, Eva BRICHTOVÁ, Ivan REKTOR, G.A. WORRELL and P. JURAK. Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone. Annals of neurology. Hoboken: John Wiley & Sons, 2017, vol. 82, No 2, p. 299-310. ISSN 0364-5134. Available from: https://dx.doi.org/10.1002/ana.25006.

@article{1401237,
   author = {Brázdil, Milan and Pail, Martin and Halamek, J. and Plesinger, F. and Cimbalnik, J. and Roman, Robert and Klimes, P. and Daniel, Pavel and Chrastina, Jan and Brichtová, Eva and Rektor, Ivan and Worrell, G.A. and Jurak, P.},
   article_location = {Hoboken},
   article_number = {2},
   doi = {http://dx.doi.org/10.1002/ana.25006},
   keywords = {Biomarkers of the Epileptogenic Zone},
   language = {eng},
   issn = {0364-5134},
   journal = {Annals of neurology},
   title = {Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone},
   volume = {82},
   year = {2017}
}

TY  - JOUR
ID  - 1401237
AU  - Brázdil, Milan - Pail, Martin - Halamek, J. - Plesinger, F. - Cimbalnik, J. - Roman, Robert - Klimes, P. - Daniel, Pavel - Chrastina, Jan - Brichtová, Eva - Rektor, Ivan - Worrell, G.A. - Jurak, P.
PY  - 2017
TI  - Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone
JF  - Annals of neurology
VL  - 82
IS  - 2
SP  - 299-310
EP  - 299-310
PB  - John Wiley & Sons
SN  - 03645134
KW  - Biomarkers of the Epileptogenic Zone
N2  - Objective: In the present study, we aimed to investigate depth electroencephalographic (EEG) recordings in a large cohort of patients with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) between 500Hz and 2kHz. We hypothesized that interictal VHFOs are more specific biomarkers for epileptogenic zone compared to traditional HFOs. Methods: Forty patients with focal epilepsy who underwent presurgical stereo-EEG (SEEG) were included in the study. SEEG data were recorded with a sampling rate of 25kHz, and a 30-minute resting period was analyzed for each patient. Ten patients met selected criteria for analyses of correlations with surgical outcome: detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs; resective surgery; and at least 1 year of postoperative follow-up. Using power envelope computation and visual inspection of power distribution matrixes, electrode contacts with HFOs and VHFOs were detected and analyzed. Results: Interictal very fast ripples (VFRs; 500-1,000Hz) were detected in 23 of 40 patients and ultrafast ripples (UFRs; 1,000-2,000Hz) in almost half of investigated subjects (n=19). VFRs and UFRs were observed only in patients with temporal lobe epilepsy and were recorded exclusively from mesiotemporal structures. The UFRs were more spatially restricted in the brain than lower-frequency HFOs. When compared to R oscillations, significantly better outcomes were observed in patients with a higher percentage of removed contacts containing FRs, VFRs, and UFRs. Interpretation: Interictal VHFOs are relatively frequent abnormal phenomena in patients with epilepsy, and appear to be more specific biomarkers for epileptogenic zone when compared to traditional HFOs.
ER  -

BRÁZDIL, Milan, Martin PAIL, J. HALAMEK, F. PLESINGER, J. CIMBALNIK, Robert ROMAN, P. KLIMES, Pavel DANIEL, Jan CHRASTINA, Eva BRICHTOVÁ, Ivan REKTOR, G.A. WORRELL and P. JURAK. Very High-Frequency Oscillations: Novel Biomarkers of the Epileptogenic Zone. \textit{Annals of neurology}. Hoboken: John Wiley \&{} Sons, 2017, vol.~82, No~2, p.~299-310. ISSN~0364-5134. Available from: https://dx.doi.org/10.1002/ana.25006.

Detailed Information on Publication Record