KRALICKOVA, P., J. KUHNOVA, O. SOUCEK, P. VODAREK, P. ZAK, M. SIMKOVIC, M. MOTYCKOVA, L. SMOLEJ, E. MALA, C. ANDRYS, J. KREJSEK and Vojtěch THON. Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies. Journal of Immunology Research. London: Hindawi, 2017, vol. 2017, No 7304658, p. 1-8. ISSN 2314-8861. Available from: https://dx.doi.org/10.1155/2017/7304658.
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Basic information
Original name Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies
Authors KRALICKOVA, P. (203 Czech Republic), J. KUHNOVA (203 Czech Republic), O. SOUCEK (203 Czech Republic), P. VODAREK (203 Czech Republic), P. ZAK (203 Czech Republic), M. SIMKOVIC (203 Czech Republic), M. MOTYCKOVA (203 Czech Republic), L. SMOLEJ (203 Czech Republic), E. MALA (203 Czech Republic), C. ANDRYS (203 Czech Republic), J. KREJSEK (203 Czech Republic) and Vojtěch THON (203 Czech Republic, guarantor, belonging to the institution).
Edition Journal of Immunology Research, London, Hindawi, 2017, 2314-8861.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.298
RIV identification code RIV/00216224:14110/17:00099077
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1155/2017/7304658
UT WoS 000419035800001
Keywords in English Pneumococcal Capsular Polysaccharides; Natural Anti-Galactosyl; Humoral Immunodeficiencies
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 21/3/2018 16:27.
Abstract
Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patients with chronic lymphocytic leukaemia (CLL), (2) patients with common variable immunodeficiency (CVID), and (3) a healthy population and to explore their diagnostic and prognostic potential. Serum immunoglobulin levels and levels of anti-Gal IgG, IgA, and IgM and anti-PCP IgG and IgG2 were determined in 59 CLL patients, 30 CVID patients, and 67 healthy controls. Levels of IgG, IgA, IgM, anti-Gal IgA, anti-Gal IgM, and anti-PCP IgA were lower in CLL and CVID patients than in healthy controls. Decrease in the levels of IgA, IgM, anti-Gal IgA, and anti-PCP IgA was less pronounced in the CLL group than in the CVID group. IgA decline, anti-Gal IgA, anti-PCP IgA, and anti-PCP IgG2 were negatively correlated with CLL stage. We devise the evaluation of anti-Gal antibodies to be a routine test in humoral immunodeficiency diagnostics, even in cases of immunoglobulin substitution therapy. Significant reductions, mainly in anti-Gal IgA, IgM, and anti-PCP IgA levels, may have prognostic importance in CLL patients.
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