NECHVÁTALOVÁ, Jana, Tomáš PAVLÍK, Jiří LITZMAN a Marcela VLKOVÁ. Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency. CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY. POZNAN: TERMEDIA PUBLISHING HOUSE LTD, 2017, roč. 42, č. 3, s. 244-251. ISSN 1426-3912. doi:10.5114/ceji.2017.70966.
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Základní údaje
Originální název Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency
Autoři NECHVÁTALOVÁ, Jana (203 Česká republika, domácí), Tomáš PAVLÍK (203 Česká republika, domácí), Jiří LITZMAN (203 Česká republika, garant, domácí) a Marcela VLKOVÁ (203 Česká republika, domácí).
Vydání CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, POZNAN, TERMEDIA PUBLISHING HOUSE LTD, 2017, 1426-3912.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30102 Immunology
Stát vydavatele Polsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.787
Kód RIV RIV/00216224:14110/17:00095689
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.5114/ceji.2017.70966
UT WoS 000415131100004
Klíčová slova anglicky IgA deficiency; common variable immunodeficiency; T-lymphocyte subpopulations; CMV
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 5. 1. 2018 13:24.
Anotace
Introduction: Previous studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder-selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. Material and methods: Using flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naive CD45RO(-)CD27(+), early differentiated CD45RO(+)CD27(+), late differentiated CD45RO(+) CD27(-)and fully differentiated effector CD45RO(-)CD27(-)memory T cells, as well as Treg cells, defined as CD4(+) CD25highCD127 low T cells. Results: An increase of CD4(+) and CD8(+) late differentiated memory cells was observed comparing CVID patients to controls, as well as comparing IgAD patients to controls. In CVID patients an increase of CD4(+) early differentiated memory cells, a decrease of CD8(+) intermediate memory cells, and CD4(+) and CD8(+) naive cells were found as well. The abnormalities in IgAD patients might be explained by higher CMV seropositivity observed in our IgAD. We confirmed the repeatedly published decrease of Treg cells in CVID patients, while Treg cells in IgAD patients were increased compared to controls. Conclusions: Our results show T-cell activation not only in CVID, but also in IgAD patients. The increase in IgAD patients may be influenced by a more frequent CMV infection in our group of IgAD patients.
Návaznosti
NV15-28732A, projekt VaVNázev: Vliv granulocytů a monocytů na vznik a rozvoj imunodeficitních chorob a dalších imunopatologických dějů
VytisknoutZobrazeno: 27. 2. 2021 19:13