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@article{1401257,
author = {Nechvátalová, Jana and Pavlík, Tomáš and Litzman, Jiří and Vlková, Marcela},
article_location = {POZNAN},
article_number = {3},
doi = {http://dx.doi.org/10.5114/ceji.2017.70966},
keywords = {IgA deficiency; common variable immunodeficiency; T-lymphocyte subpopulations; CMV},
language = {eng},
issn = {1426-3912},
journal = {CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY},
title = {Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency},
volume = {42},
year = {2017}
}
TY - JOUR
ID - 1401257
AU - Nechvátalová, Jana - Pavlík, Tomáš - Litzman, Jiří - Vlková, Marcela
PY - 2017
TI - Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency
JF - CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
VL - 42
IS - 3
SP - 244-251
EP - 244-251
PB - TERMEDIA PUBLISHING HOUSE LTD
SN - 14263912
KW - IgA deficiency
KW - common variable immunodeficiency
KW - T-lymphocyte subpopulations
KW - CMV
N2 - Introduction: Previous studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder-selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. Material and methods: Using flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naive CD45RO(-)CD27(+), early differentiated CD45RO(+)CD27(+), late differentiated CD45RO(+) CD27(-)and fully differentiated effector CD45RO(-)CD27(-)memory T cells, as well as Treg cells, defined as CD4(+) CD25highCD127 low T cells. Results: An increase of CD4(+) and CD8(+) late differentiated memory cells was observed comparing CVID patients to controls, as well as comparing IgAD patients to controls. In CVID patients an increase of CD4(+) early differentiated memory cells, a decrease of CD8(+) intermediate memory cells, and CD4(+) and CD8(+) naive cells were found as well. The abnormalities in IgAD patients might be explained by higher CMV seropositivity observed in our IgAD. We confirmed the repeatedly published decrease of Treg cells in CVID patients, while Treg cells in IgAD patients were increased compared to controls. Conclusions: Our results show T-cell activation not only in CVID, but also in IgAD patients. The increase in IgAD patients may be influenced by a more frequent CMV infection in our group of IgAD patients.
ER -
NECHVÁTALOVÁ, Jana, Tomáš PAVLÍK, Jiří LITZMAN a Marcela VLKOVÁ. Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency. \textit{CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY}. POZNAN: TERMEDIA PUBLISHING HOUSE LTD, 2017, roč.~42, č.~3, s.~244-251. ISSN~1426-3912. Dostupné z: https://dx.doi.org/10.5114/ceji.2017.70966.
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