J 2017

Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency

NECHVÁTALOVÁ, Jana, Tomáš PAVLÍK, Jiří LITZMAN and Marcela VLKOVÁ

Basic information

Original name

Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency

Authors

NECHVÁTALOVÁ, Jana (203 Czech Republic, belonging to the institution), Tomáš PAVLÍK (203 Czech Republic, belonging to the institution), Jiří LITZMAN (203 Czech Republic, guarantor, belonging to the institution) and Marcela VLKOVÁ (203 Czech Republic, belonging to the institution)

Edition

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, POZNAN, TERMEDIA PUBLISHING HOUSE LTD, 2017, 1426-3912

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.787

RIV identification code

RIV/00216224:14110/17:00095689

Organization unit

Faculty of Medicine

DOI

UT WoS

000415131100004

Keywords in English

IgA deficiency; common variable immunodeficiency; T-lymphocyte subpopulations; CMV

Tags

Tags

International impact, Reviewed
Změněno: 5/1/2018 13:24, Soňa Böhmová

Abstract

V originále

Introduction: Previous studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder-selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. Material and methods: Using flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naive CD45RO(-)CD27(+), early differentiated CD45RO(+)CD27(+), late differentiated CD45RO(+) CD27(-)and fully differentiated effector CD45RO(-)CD27(-)memory T cells, as well as Treg cells, defined as CD4(+) CD25highCD127 low T cells. Results: An increase of CD4(+) and CD8(+) late differentiated memory cells was observed comparing CVID patients to controls, as well as comparing IgAD patients to controls. In CVID patients an increase of CD4(+) early differentiated memory cells, a decrease of CD8(+) intermediate memory cells, and CD4(+) and CD8(+) naive cells were found as well. The abnormalities in IgAD patients might be explained by higher CMV seropositivity observed in our IgAD. We confirmed the repeatedly published decrease of Treg cells in CVID patients, while Treg cells in IgAD patients were increased compared to controls. Conclusions: Our results show T-cell activation not only in CVID, but also in IgAD patients. The increase in IgAD patients may be influenced by a more frequent CMV infection in our group of IgAD patients.

Links

NV15-28732A, research and development project
Name: Vliv granulocytů a monocytů na vznik a rozvoj imunodeficitních chorob a dalších imunopatologických dějů