PÁSEK, Michal, Markéta BÉBAROVÁ and Georges CHRISTÉ. A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces. In Vladimír Fuis. Engineering Mechanics 2017. Prague: Academy of Sciences of the Czech Republic, 2017, p. 750-753. ISBN 978-80-214-5497-2.
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Basic information
Original name A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces
Authors PÁSEK, Michal (203 Czech Republic), Markéta BÉBAROVÁ (203 Czech Republic, guarantor, belonging to the institution) and Georges CHRISTÉ (250 France).
Edition Prague, Engineering Mechanics 2017, p. 750-753, 4 pp. 2017.
Publisher Academy of Sciences of the Czech Republic
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 20300 2.3 Mechanical engineering
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
WWW URL
RIV identification code RIV/00216224:14110/17:00095690
Organization unit Faculty of Medicine
ISBN 978-80-214-5497-2
ISSN 1805-8248
UT WoS 000411657600177
Keywords in English Human ventricular cell model; T-tubules; Dyads; Subsarcolemmal spaces; Calcium cycling
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 12/4/2018 10:34.
Abstract
Intracellular Ca2+ load and Ca2+ transient are considerably dependent on distribution of sarcolemmal Ca2+ pump and Na+-Ca2+ exchanger between the t-tubular and surface membranes in the presence of separate dyadic and subsarcolemmal spaces in rat ventricular cell model. To explore analogical phenomenon in human, we modified our previously published model of human ventricular myocyte. When the t-tubular fractions of Na+-Ca2+ exchanger and of sarcolemmal Ca2+ pump were increased to the newly proposed value of 0.95 in the modified model, the following changes were observed at 1 Hz steady-state stimulation: a shortening of the action potential duration at 90 % repolarisation by 6 % and an increase of the cytosolic Ca2+ transient by 22 %. Further analysis revealed a critical role of Ca2+ concentration changes in the subsarcolemmal spaces and consequent change in cellular Ca2+ cycling in this effect.
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NV16-30571A, research and development projectName: Klinický význam a elektrofyziologické zhodnocení mutace c.926C>T genu KCNQ1 (p.T309I) jako možné „founder mutation“ syndromu dlouhého intervalu QT
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