A modified mathematical model of human ventricular
cardiomyocyte incorporating separate t-tubular and surface
dyads and submembrane spaces

D 2017

A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces

PÁSEK, Michal, Markéta BÉBAROVÁ and Georges CHRISTÉ

Basic information

Original name

A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces

Authors

PÁSEK, Michal (203 Czech Republic), Markéta BÉBAROVÁ (203 Czech Republic, guarantor, belonging to the institution) and Georges CHRISTÉ (250 France)

Edition

Prague, Engineering Mechanics 2017, p. 750-753, 4 pp. 2017

Publisher

Academy of Sciences of the Czech Republic

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

20300 2.3 Mechanical engineering

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

RIV identification code

RIV/00216224:14110/17:00095690

Organization unit

Faculty of Medicine

ISBN

978-80-214-5497-2

ISSN

UT WoS

000411657600177

Keywords in English

Human ventricular cell model; T-tubules; Dyads; Subsarcolemmal spaces; Calcium cycling

Abstract

V originále

Intracellular Ca2+ load and Ca2+ transient are considerably dependent on distribution of sarcolemmal Ca2+ pump and Na+-Ca2+ exchanger between the t-tubular and surface membranes in the presence of separate dyadic and subsarcolemmal spaces in rat ventricular cell model. To explore analogical phenomenon in human, we modified our previously published model of human ventricular myocyte. When the t-tubular fractions of Na+-Ca2+ exchanger and of sarcolemmal Ca2+ pump were increased to the newly proposed value of 0.95 in the modified model, the following changes were observed at 1 Hz steady-state stimulation: a shortening of the action potential duration at 90 % repolarisation by 6 % and an increase of the cytosolic Ca2+ transient by 22 %. Further analysis revealed a critical role of Ca2+ concentration changes in the subsarcolemmal spaces and consequent change in cellular Ca2+ cycling in this effect.

Links

NV16-30571A, research and development project

Name: Klinický význam a elektrofyziologické zhodnocení mutace c.926C>T genu KCNQ1 (p.T309I) jako možné „founder mutation“ syndromu dlouhého intervalu QT

Citovat

PÁSEK, Michal, Markéta BÉBAROVÁ and Georges CHRISTÉ. A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces. In Vladimír Fuis. Engineering Mechanics 2017. Prague: Academy of Sciences of the Czech Republic, 2017, p. 750-753. ISBN 978-80-214-5497-2.

@inproceedings{1401259,
   author = {Pásek, Michal and Bébarová, Markéta and Christé, Georges},
   address = {Prague},
   booktitle = {Engineering Mechanics 2017},
   editor = {Vladimír Fuis},
   keywords = {Human ventricular cell model; T-tubules; Dyads; Subsarcolemmal spaces; Calcium cycling},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Prague},
   isbn = {978-80-214-5497-2},
   pages = {750-753},
   publisher = {Academy of Sciences of the Czech Republic},
   title = {A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces},
   url = {http://www.engmech.cz/2017/im/doc/EM2017_proceedings_all.pdf},
   year = {2017}
}

TY  - JOUR
ID  - 1401259
AU  - Pásek, Michal - Bébarová, Markéta - Christé, Georges
PY  - 2017
TI  - A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces
PB  - Academy of Sciences of the Czech Republic
CY  - Prague
SN  - 9788021454972
KW  - Human ventricular cell model
KW  - T-tubules
KW  - Dyads
KW  - Subsarcolemmal spaces
KW  - Calcium cycling
UR  - http://www.engmech.cz/2017/im/doc/EM2017_proceedings_all.pdf
L2  - http://www.engmech.cz/2017/im/doc/EM2017_proceedings_all.pdf
N2  - Intracellular Ca2+ load and Ca2+ transient are considerably dependent on distribution of sarcolemmal Ca2+ pump and Na+-Ca2+ exchanger between the t-tubular and surface membranes in the presence of separate dyadic and subsarcolemmal spaces in rat ventricular cell model. To explore analogical phenomenon in human, we modified our previously published model of human ventricular myocyte. When the t-tubular fractions of Na+-Ca2+ exchanger and of sarcolemmal Ca2+ pump were increased to the newly proposed value of 0.95 in the modified model, the following changes were observed at 1 Hz steady-state stimulation: a shortening of the action potential duration at 90 % repolarisation by 6 % and an increase of the cytosolic Ca2+ transient by 22 %. Further analysis revealed a critical role of Ca2+ concentration changes in the subsarcolemmal spaces and consequent change in cellular Ca2+ cycling in this effect.
ER  -

PÁSEK, Michal, Markéta BÉBAROVÁ and Georges CHRISTÉ. A modified mathematical model of human ventricular cardiomyocyte incorporating separate t-tubular and surface dyads and submembrane spaces. In Vladimír Fuis. \textit{Engineering Mechanics 2017}. Prague: Academy of Sciences of the Czech Republic, 2017, p.~750-753. ISBN~978-80-214-5497-2.

Detailed Information on Publication Record