J 2017

Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis

SCHMIDT, T., M. HOCH, S.S. LOFTI JAD, F. SOLIMANI, G. DI ZENZO et. al.

Basic information

Original name

Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis

Authors

SCHMIDT, T. (276 Germany), M. HOCH (276 Germany), S.S. LOFTI JAD (276 Germany), F. SOLIMANI (276 Germany), G. DI ZENZO (380 Italy), A.V. MARZANO (380 Italy), M. GOEBELER (276 Germany), E. COZZANI (380 Italy), J.S. KERN (276 Germany), C. SITARU (276 Germany), I. LAKOŠ JUKIĆ (191 Croatia), M. SÁRDY (276 Germany), S. UZUN (792 Turkey), Hana JEDLIČKOVÁ (203 Czech Republic, guarantor, belonging to the institution), R. GLÄSER (276 Germany), M. KANEDA (392 Japan), R. EMING (276 Germany), G. GÖPEL (276 Germany), N. ISHII (392 Japan), B. GREENE (276 Germany), T. HASHIMOTO (392 Japan) and M. HERTL (276 Germany)

Edition

British Journal of Dermatology, Hoboken, Wiley, 2017, 0007-0963

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 6.129

RIV identification code

RIV/00216224:14110/17:00099150

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/bjd.15800

UT WoS

000419479300057

Keywords in English

Epidermolysis bullosa acquisita

Tags

EL OK

Tags

International impact, Reviewed
Změněno: 20/3/2018 17:59, Soňa Böhmová

Abstract

V originále

Epidermolysis bullosa acquisita (EBA) is a rare, potentially devastating autoimmune disease of the skin. IgG autoantibodies directed against type VII collagen (Col7), the major component of anchoring fibrils, induce skin fragility leading to cutaneous and mucocutaneous blister formation, which is mostly of a scarring phenotype. Thus, powerful and reproducible diagnostic assays are critical to establish the diagnosis of EBA early to avoid irreversible sequelae.
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