| SMID, D.E., F.M.E. FRANSSEN, M. GONIK, M. MIRAVITLLES, C. CASANOVA, B.G. COSIO, P. de LUCAS-RAMOS, J.M. MARIN, C. MARTINEZ, I. MIR, J.B. SORIANO, J.P. de TORRES, A. AGUSTI, N.B. ATALAY, J. BILLINGTON, A.K. BOUTOU, S. BRIGHENTI-ZOGG, E. CHAPLIN, S. COSTER, J.W. DODD, S. DURR, A. FERNANDEZ-VILLAR, M.T.J. GROENEN, M. GUIMARAES, Karel HEJDUK, V. HIGGINS, N.S. HOPKINSON, N. HORITA, S. HOUBEN-WILKE, D.J.A. JANSSEN, M. JEHN, R. JOERRES, A. KARCH, J.L. KELLY, Y.I. KIM, H. KIMURA, V. KOBLIZEK, J.H. KOCKS, S.S.C. KON, N. KWON, I. LADEIRA, S.D. LEE, J.D. LEUPPI, N. LOCANTORE, J.L. LOPEZ-CAMPOS, W.D.C. MAN, L. MARICIC, L. MENDOZA, D. MIEDINGER, F. MIHALTAN, S. MINAMI, T. van der MOLEN, T.J. MURRELLS, N. NAKKEN, Y. NISHIJIMA, I.J. NORMAN, B. NOVOTNA, D.E. O DONNELL, Y. OGATA, E.D. PEREIRA, J. PIERCY, D. PRICE, C. POTHIRAT, N. RAGHAVAN, T. RINGBAEK, D. SAJKOV, N. SIGARI, S. SINGH, M. SMALL, G.F. DA SILVA, R.J. TANNER, I.G. TSILIGIANNI, B. TULEK, N. TZANAKIS, L.E.G.W. VANFLETEREN, H. WATZ, K.A. WEBB, E.F.M. WOUTERS, G.G. XIE, M. YOSHIKAWA and M.A. SPRUIT. Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. NEW YORK: ELSEVIER SCIENCE INC, 2017, vol. 18, No 12, p. 1-14. ISSN 1525-8610. Available from: https://dx.doi.org/10.1016/j.jamda.2017.09.003. |
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@article{1402050,
author = {Smid, D.E. and Franssen, F.M.E. and Gonik, M. and Miravitlles, M. and Casanova, C. and Cosio, B.G. and LucasandRamos, P. de and Marin, J.M. and Martinez, C. and Mir, I. and Soriano, J.B. and Torres, J.P. de and Agusti, A. and Atalay, N.B. and Billington, J. and Boutou, A.K. and BrighentiandZogg, S. and Chaplin, E. and Coster, S. and Dodd, J.W. and Durr, S. and FernandezandVillar, A. and Groenen, M.T.J. and Guimaraes, M. and Hejduk, Karel and Higgins, V. and Hopkinson, N.S. and Horita, N. and HoubenandWilke, S. and Janssen, D.J.A. and Jehn, M. and Joerres, R. and Karch, A. and Kelly, J.L. and Kim, Y.I. and Kimura, H. and Koblizek, V. and Kocks, J.H. and Kon, S.S.C. and Kwon, N. and Ladeira, I. and Lee, S.D. and Leuppi, J.D. and Locantore, N. and LopezandCampos, J.L. and Man, W.D.C. and Maricic, L. and Mendoza, L. and Miedinger, D. and Mihaltan, F. and Minami, S. and Molen, T. van der and Murrells, T.J. and Nakken, N. and Nishijima, Y. and Norman, I.J. and Novotna, B. and O Donnell, D.E. and Ogata, Y. and Pereira, E.D. and Piercy, J. and Price, D. and Pothirat, C. and Raghavan, N. and Ringbaek, T. and Sajkov, D. and Sigari, N. and Singh, S. and Small, M. and da Silva, G.F. and Tanner, R.J. and Tsiligianni, I.G. and Tulek, B. and Tzanakis, N. and Vanfleteren, L.E.G.W. and Watz, H. and Webb, K.A. and Wouters, E.F.M. and Xie, G.G. and Yoshikawa, M. and Spruit, M.A.},
article_location = {NEW YORK},
article_number = {12},
doi = {http://dx.doi.org/10.1016/j.jamda.2017.09.003},
keywords = {COPD; GOLD; health status; clinical significance},
language = {eng},
issn = {1525-8610},
journal = {JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION},
title = {Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease},
volume = {18},
year = {2017}
}
TY - JOUR
ID - 1402050
AU - Smid, D.E. - Franssen, F.M.E. - Gonik, M. - Miravitlles, M. - Casanova, C. - Cosio, B.G. - Lucas-Ramos, P. de - Marin, J.M. - Martinez, C. - Mir, I. - Soriano, J.B. - Torres, J.P. de - Agusti, A. - Atalay, N.B. - Billington, J. - Boutou, A.K. - Brighenti-Zogg, S. - Chaplin, E. - Coster, S. - Dodd, J.W. - Durr, S. - Fernandez-Villar, A. - Groenen, M.T.J. - Guimaraes, M. - Hejduk, Karel - Higgins, V. - Hopkinson, N.S. - Horita, N. - Houben-Wilke, S. - Janssen, D.J.A. - Jehn, M. - Joerres, R. - Karch, A. - Kelly, J.L. - Kim, Y.I. - Kimura, H. - Koblizek, V. - Kocks, J.H. - Kon, S.S.C. - Kwon, N. - Ladeira, I. - Lee, S.D. - Leuppi, J.D. - Locantore, N. - Lopez-Campos, J.L. - Man, W.D.C. - Maricic, L. - Mendoza, L. - Miedinger, D. - Mihaltan, F. - Minami, S. - Molen, T. van der - Murrells, T.J. - Nakken, N. - Nishijima, Y. - Norman, I.J. - Novotna, B. - O Donnell, D.E. - Ogata, Y. - Pereira, E.D. - Piercy, J. - Price, D. - Pothirat, C. - Raghavan, N. - Ringbaek, T. - Sajkov, D. - Sigari, N. - Singh, S. - Small, M. - da Silva, G.F. - Tanner, R.J. - Tsiligianni, I.G. - Tulek, B. - Tzanakis, N. - Vanfleteren, L.E.G.W. - Watz, H. - Webb, K.A. - Wouters, E.F.M. - Xie, G.G. - Yoshikawa, M. - Spruit, M.A.
PY - 2017
TI - Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease
JF - JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
VL - 18
IS - 12
SP - 1-14
EP - 1-14
PB - ELSEVIER SCIENCE INC
SN - 15258610
KW - COPD
KW - GOLD
KW - health status
KW - clinical significance
N2 - Background: Patients with chronic obstructive pulmonary disease (COPD) can be classified into groups A/C or B/D based on symptom intensity. Different threshold values for symptom questionnaires can result in misclassification and, in turn, different treatment recommendations. The primary aim was to find the best fitting cut-points for Global initiative for chronic Obstructive Lung Disease (GOLD) symptom measures, with an modified Medical Research Council dyspnea grade of 2 or higher as point of reference. Methods: After a computerized search, data from 41 cohorts and whose authors agreed to provide data were pooled. COPD studies were eligible for analyses if they included, at least age, sex, post-bronchodilator spirometry, modified Medical Research Council, and COPD Assessment Test (CAT) total scores. Main outcomes: Receiver operating characteristic curves and the Youden index were used to determine the best calibration threshold for CAT, COPD Clinical Questionnaire, and St. Georges Respiratory Questionnaire total scores. Following, GOLD A/B/C/D frequencies were calculated based on current cut-points and the newly derived cut-points. Findings: A total of 18,577 patients with COPD [72.0% male; mean age: 66.3 years (standard deviation 9.6)] were analyzed. Most patients had a moderate or severe degree of airflow limitation (GOLD spirometric grade 1, 10.9%; grade 2, 46.6%; grade 3, 32.4%; and grade 4, 10.3%). The best calibration threshold for CAT total score was 18 points, for COPD Clinical Questionnaire total score 1.9 points, and for St. Georges Respiratory Questionnaire total score 46.0 points. Conclusions: The application of these new cut-points would reclassify about one-third of the patients with COPD and, thus, would impact on individual disease management. Further validation in prospective studies of these new values are needed. (C) 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
ER -
SMID, D.E., F.M.E. FRANSSEN, M. GONIK, M. MIRAVITLLES, C. CASANOVA, B.G. COSIO, P. de LUCAS-RAMOS, J.M. MARIN, C. MARTINEZ, I. MIR, J.B. SORIANO, J.P. de TORRES, A. AGUSTI, N.B. ATALAY, J. BILLINGTON, A.K. BOUTOU, S. BRIGHENTI-ZOGG, E. CHAPLIN, S. COSTER, J.W. DODD, S. DURR, A. FERNANDEZ-VILLAR, M.T.J. GROENEN, M. GUIMARAES, Karel HEJDUK, V. HIGGINS, N.S. HOPKINSON, N. HORITA, S. HOUBEN-WILKE, D.J.A. JANSSEN, M. JEHN, R. JOERRES, A. KARCH, J.L. KELLY, Y.I. KIM, H. KIMURA, V. KOBLIZEK, J.H. KOCKS, S.S.C. KON, N. KWON, I. LADEIRA, S.D. LEE, J.D. LEUPPI, N. LOCANTORE, J.L. LOPEZ-CAMPOS, W.D.C. MAN, L. MARICIC, L. MENDOZA, D. MIEDINGER, F. MIHALTAN, S. MINAMI, T. van der MOLEN, T.J. MURRELLS, N. NAKKEN, Y. NISHIJIMA, I.J. NORMAN, B. NOVOTNA, D.E. O DONNELL, Y. OGATA, E.D. PEREIRA, J. PIERCY, D. PRICE, C. POTHIRAT, N. RAGHAVAN, T. RINGBAEK, D. SAJKOV, N. SIGARI, S. SINGH, M. SMALL, G.F. DA SILVA, R.J. TANNER, I.G. TSILIGIANNI, B. TULEK, N. TZANAKIS, L.E.G.W. VANFLETEREN, H. WATZ, K.A. WEBB, E.F.M. WOUTERS, G.G. XIE, M. YOSHIKAWA and M.A. SPRUIT. Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease. \textit{JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION}. NEW YORK: ELSEVIER SCIENCE INC, 2017, vol.~18, No~12, p.~1-14. ISSN~1525-8610. Available from: https://dx.doi.org/10.1016/j.jamda.2017.09.003.
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