Detailed Information on Publication Record
2017
Speech disorders in Parkinson's disease: early diagnostics and effects of medication and brain stimulation
BRABENEC, Luboš, Jiří MEKYSKA, Zoltán GALÁŽ and Irena REKTOROVÁBasic information
Original name
Speech disorders in Parkinson's disease: early diagnostics and effects of medication and brain stimulation
Authors
BRABENEC, Luboš (203 Czech Republic, guarantor, belonging to the institution), Jiří MEKYSKA (203 Czech Republic), Zoltán GALÁŽ (703 Slovakia) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution)
Edition
Journal of Neural Transmission, Wien, SPRINGER WIEN, 2017, 0300-9564
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Austria
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.779
RIV identification code
RIV/00216224:14110/17:00095693
Organization unit
Faculty of Medicine
UT WoS
000394433100004
Keywords in English
Hypokinetic dysarthria; Parkinson’s disease; Acoustic analysis; rTMS; DBS; Dopaminergic medication; Functional imaging
Tags
International impact, Reviewed
Změněno: 13/3/2018 19:43, Soňa Böhmová
Abstract
V originále
Hypokinetic dysarthria (HD) occurs in 90% of Parkinson’s disease (PD) patients. It manifests specifically in the areas of articulation, phonation, prosody, speech fluency, and faciokinesis. We aimed to systematically review papers on HD in PD with a special focus on (1) early PD diagnosis and monitoring of the disease progression using acoustic voice and speech analysis, and (2) functional imaging studies exploring neural correlates of HD in PD, and (3) clinical studies using acoustic analysis to evaluate effects of dopaminergic medication and brain stimulation. A systematic literature search of articles written in English before March 2016 was conducted in the Web of Science, PubMed, SpringerLink, and IEEE Xplore databases using and combining specific relevant keywords. Articles were categorized into three groups: (1) articles focused on neural correlates of HD in PD using functional imaging (n = 13); (2) articles dealing with the acoustic analysis of HD in PD (n = 52); and (3) articles concerning specifically dopaminergic and brain stimulation-related effects as assessed by acoustic analysis (n = 31); the groups were then reviewed. We identified 14 combinations of speech tasks and acoustic features that can be recommended for use in describing the main features of HD in PD. While only a few acoustic parameters correlate with limb motor symptoms and can be partially relieved by dopaminergic medication, HD in PD seems to be mainly related to non-dopaminergic deficits and associated particularly with non-motor symptoms. Future studies should combine non-invasive brain stimulation with voice behavior approaches to achieve the best treatment effects by enhancing auditory-motor integration.
Links
| NV16-30805A, research and development project |
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