Predictive value of preoperative statistical parametric mapping
of regional glucose metabolism in mesial temporal lobe epilepsy
with hippocampal sclerosis

J 2018

Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis

KOJAN, Martin, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Radek MAREČEK, Zdeněk ŘEHÁK et. al.

Basic information

Original name

Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis

Authors

KOJAN, Martin (703 Slovakia, belonging to the institution), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Zdeněk ŘEHÁK (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

EPILEPSY & BEHAVIOR, Elsevier, 2018, 1525-5050

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.378

RIV identification code

RIV/00216224:14740/18:00102189

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.yebeh.2017.11.014

UT WoS

000426435800009

Keywords in English

positron emission tomography; FDG-PET; mesial temporal lobe epilepsy; hippocampal sclerosis

Abstract

V originále

OBJECTIVE: This study was designed to use statistical parametric mapping of interictal positron-emission tomography using [18F]Fluorodeoxyglucose (FDG-PET) to compare the brain metabolisms of patients with mesial temporal lobe epilepsy (MTLE)/hippocampal sclerosis and controls. Another aim of this study was to analyze the potential differences among patients in terms of epilepsy duration, side of hippocampal sclerosis, histopathological findings, insult in their history, and postoperative outcomes. METHODS: We analyzed FDG-PET scans from 49 patients with MTLE/hippocampal sclerosis and 24 control subjects. We analyzed the differences in regional glucose metabolism between the patients and the control group and within the patient group using multiple variables. RESULTS: We observed widespread hypometabolism in the patient group in comparison with the control group in temporal and extratemporal areas on the epileptogenic side (ES). On the nonepileptogenic side (NES), we observed the most hypometabolism in the thalamus and the anterior and middle cingulate gyrus. In the group of patients with more severe hippocampal sclerosis, we observed statistically significant hypometabolism in the insula on the ES. In patients with poor postoperative outcomes, we found statistically significant hypometabolism in the insula on the ES and the temporal pole (TP) on the NES. Patients with any insult in their history showed hypermetabolism in the TP on both sides. CONCLUSION: Our study showed that there are widespread changes in metabolism in patients with MTLE in comparison to controls, either inside or outside the temporal lobe. There are significant differences among these patients in terms of postoperative outcomes, degree of hippocampal sclerosis, and insults in their history.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

KOJAN, Martin, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Radek MAREČEK, Zdeněk ŘEHÁK, Markéta HERMANOVÁ, Milan BRÁZDIL and Ivan REKTOR. Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. EPILEPSY & BEHAVIOR. Elsevier, 2018, vol. 79, DEC, p. 46-52. ISSN 1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2017.11.014.

@article{1403104,
   author = {Kojan, Martin and Doležalová, Irena and Koriťáková, Eva and Mareček, Radek and Řehák, Zdeněk and Hermanová, Markéta and Brázdil, Milan and Rektor, Ivan},
   article_number = {DEC},
   doi = {http://dx.doi.org/10.1016/j.yebeh.2017.11.014},
   keywords = {positron emission tomography; FDG-PET; mesial temporal lobe epilepsy; hippocampal sclerosis},
   language = {eng},
   issn = {1525-5050},
   journal = {EPILEPSY & BEHAVIOR},
   title = {Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis},
   url = {http://www.sciencedirect.com/science/article/pii/S1525505017305267?via%3Dihub},
   volume = {79},
   year = {2018}
}

TY  - JOUR
ID  - 1403104
AU  - Kojan, Martin - Doležalová, Irena - Koriťáková, Eva - Mareček, Radek - Řehák, Zdeněk - Hermanová, Markéta - Brázdil, Milan - Rektor, Ivan
PY  - 2018
TI  - Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis
JF  - EPILEPSY & BEHAVIOR
VL  - 79
IS  - DEC
SP  - 46-52
EP  - 46-52
PB  - Elsevier
SN  - 15255050
KW  - positron emission tomography
KW  - FDG-PET
KW  - mesial temporal lobe epilepsy
KW  - hippocampal sclerosis
UR  - http://www.sciencedirect.com/science/article/pii/S1525505017305267?via%3Dihub
N2  - OBJECTIVE: This study was designed to use statistical parametric mapping of interictal positron-emission tomography using [18F]Fluorodeoxyglucose (FDG-PET) to compare the brain metabolisms of patients with mesial temporal lobe epilepsy (MTLE)/hippocampal sclerosis and controls. Another aim of this study was to analyze the potential differences among patients in terms of epilepsy duration, side of hippocampal sclerosis, histopathological findings, insult in their history, and postoperative outcomes. METHODS: We analyzed FDG-PET scans from 49 patients with MTLE/hippocampal sclerosis and 24 control subjects. We analyzed the differences in regional glucose metabolism between the patients and the control group and within the patient group using multiple variables. RESULTS: We observed widespread hypometabolism in the patient group in comparison with the control group in temporal and extratemporal areas on the epileptogenic side (ES). On the nonepileptogenic side (NES), we observed the most hypometabolism in the thalamus and the anterior and middle cingulate gyrus. In the group of patients with more severe hippocampal sclerosis, we observed statistically significant hypometabolism in the insula on the ES. In patients with poor postoperative outcomes, we found statistically significant hypometabolism in the insula on the ES and the temporal pole (TP) on the NES. Patients with any insult in their history showed hypermetabolism in the TP on both sides. CONCLUSION: Our study showed that there are widespread changes in metabolism in patients with MTLE in comparison to controls, either inside or outside the temporal lobe. There are significant differences among these patients in terms of postoperative outcomes, degree of hippocampal sclerosis, and insults in their history.
ER  -

KOJAN, Martin, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Radek MAREČEK, Zdeněk ŘEHÁK, Markéta HERMANOVÁ, Milan BRÁZDIL and Ivan REKTOR. Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis. \textit{EPILEPSY \&{} BEHAVIOR}. Elsevier, 2018, vol.~79, DEC, p.~46-52. ISSN~1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2017.11.014.

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