Non-Invasive Assessment of Vascular System Function and Damage
Induced by Anthracycline Treatment in the Pediatric Cancer
Survivors

J 2017

Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors

BUDINSKAYA, Ksenia, Veronika PUCHNEROVÁ, Jana SVAČINOVÁ, Jan NOVÁK, Hana HRSTKOVÁ et. al.

Basic information

Original name

Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors

Authors

BUDINSKAYA, Ksenia (643 Russian Federation, belonging to the institution), Veronika PUCHNEROVÁ (203 Czech Republic, belonging to the institution), Jana SVAČINOVÁ (203 Czech Republic, guarantor, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Hana HRSTKOVÁ (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Anna PEKAŘOVÁ (203 Czech Republic, belonging to the institution), Matej PEKAŘ (703 Slovakia, belonging to the institution) and Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Praha, Fyziologický ústav AV ČR, 2017, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.324

RIV identification code

RIV/00216224:14110/17:00099503

Organization unit

Faculty of Medicine

UT WoS

000422901400014

Keywords in English

Anthracyclines; Cardiotoxicity; Pulse wave velocity; Pulse wave analysis; Arterial stiffness

Abstract

V originále

Anthracyclines represent one of the important classes of anti-cancer drugs; however, their major disadvantage is their profound cardiovascular toxicity. This study aimed to evaluate influence of anthracyclines on cardiovascular stiffness parameters estimated from pulse wave (PW). PW was measured in 59 cancer survivors treated with anthracyclines in childhood and in 248 healthy age-matched controls. Both patients and controls were divided into three age groups (13 – 15, 16 – 18 and 19 – 24 years). Central PW augmentation index (C-AI75) and augmentation pressure (C-AP75), both normalized to heart rate 75 bpm, were calculated as parameters of arterial wall stiffness. Central Buckberg sub-endocardial viability ratio (SEVR) was calculated as a parameter of diastolic function. Patients and controls were compared in each age group. C-AI75 and C-AP75 were significantly increased in patients in age groups 16 – 18 and 19 – 24 years. SEVR was decreased in patients in the oldest age group. Our results suggest that although toxic influence of anthracyclines to arterial wall and heart are developing during childhood and puberty, they can be detected rather in the adulthood. These changes are yet subclinical; however, their presence ndicates potentially increased cardiovascular risk in childhood cancer survivors treated with anthracyclines during childhood.

Links

MUNI/A/1355/2016, interní kód MU

Name: Kardiovaskulární systém očima molekulární fyziologie

Investor: Masaryk University, Category A

Citovat

BUDINSKAYA, Ksenia, Veronika PUCHNEROVÁ, Jana SVAČINOVÁ, Jan NOVÁK, Hana HRSTKOVÁ, Marie NOVÁKOVÁ, Anna PEKAŘOVÁ, Matej PEKAŘ and Zuzana NOVÁKOVÁ. Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors. Physiological Research. Praha: Fyziologický ústav AV ČR, 2017, vol. 66, Suppl. 4, p. "S553"-"S560", 8 pp. ISSN 0862-8408.

@article{1404202,
   author = {Budinskaya, Ksenia and Puchnerová, Veronika and Svačinová, Jana and Novák, Jan and Hrstková, Hana and Nováková, Marie and Pekařová, Anna and Pekař, Matej and Nováková, Zuzana},
   article_location = {Praha},
   article_number = {Suppl. 4},
   keywords = {Anthracyclines; Cardiotoxicity; Pulse wave velocity; Pulse wave analysis; Arterial stiffness},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors},
   volume = {66},
   year = {2017}
}

TY  - JOUR
ID  - 1404202
AU  - Budinskaya, Ksenia - Puchnerová, Veronika - Svačinová, Jana - Novák, Jan - Hrstková, Hana - Nováková, Marie - Pekařová, Anna - Pekař, Matej - Nováková, Zuzana
PY  - 2017
TI  - Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors
JF  - Physiological Research
VL  - 66
IS  - Suppl. 4
SP  - "S553"-"S560"
EP  - "S553"-"S560"
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - Anthracyclines
KW  - Cardiotoxicity
KW  - Pulse wave velocity
KW  - Pulse wave analysis
KW  - Arterial stiffness
N2  - Anthracyclines represent one of the important classes of anti-cancer drugs; however, their major disadvantage is their profound cardiovascular toxicity. This study aimed to evaluate influence of anthracyclines on cardiovascular stiffness parameters estimated from pulse wave (PW). PW was measured in 59 cancer survivors treated with anthracyclines in childhood and in 248 healthy age-matched controls. Both patients and controls were divided into three age groups (13 – 15, 16 – 18 and 19 – 24 years). Central PW augmentation index (C-AI75) and augmentation pressure (C-AP75), both normalized to heart rate 75 bpm, were calculated as parameters of arterial wall stiffness. Central Buckberg sub-endocardial viability ratio (SEVR) was calculated as a parameter of diastolic function. Patients and controls were compared in each age group. C-AI75 and C-AP75 were significantly increased in patients in age groups 16 – 18 and 19 – 24 years. SEVR was decreased in patients in the oldest age group. Our results suggest that although toxic influence of anthracyclines to arterial wall and heart are developing during childhood and puberty, they can be detected rather in the adulthood. These changes are yet subclinical; however, their presence ndicates potentially increased cardiovascular risk in childhood cancer survivors treated with anthracyclines during childhood.
ER  -

BUDINSKAYA, Ksenia, Veronika PUCHNEROVÁ, Jana SVAČINOVÁ, Jan NOVÁK, Hana HRSTKOVÁ, Marie NOVÁKOVÁ, Anna PEKAŘOVÁ, Matej PEKAŘ and Zuzana NOVÁKOVÁ. Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2017, vol.~66, Suppl. 4, p.~''S553''-''S560'', 8 pp. ISSN~0862-8408.

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