KOCIAN, P., A. WHITLEY, Milan BLAHA and J. HOCH. Colorectal cancer in patients under the age of 40 years: experience from a tertiary care centre in the Czech Republic. Acta Chirurgica Belgica. Brussels: ACTA MEDICAL BELGICA, vol. 117, No 6, p. 356-362. ISSN 0001-5458. doi:10.1080/00015458.2017.1321270. 2017.
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Basic information
Original name Colorectal cancer in patients under the age of 40 years: experience from a tertiary care centre in the Czech Republic
Authors KOCIAN, P. (203 Czech Republic), A. WHITLEY (826 United Kingdom of Great Britain and Northern Ireland), Milan BLAHA (203 Czech Republic, guarantor, belonging to the institution) and J. HOCH (203 Czech Republic).
Edition Acta Chirurgica Belgica, Brussels, ACTA MEDICAL BELGICA, 2017, 0001-5458.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30212 Surgery
Country of publisher Belgium
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.420
RIV identification code RIV/00216224:14110/17:00099601
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1080/00015458.2017.1321270
UT WoS 000419273900002
Keywords in English Colorectal cancer; young patients; prognostic factors
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 20/3/2018 18:05.
Abstract
Introduction: Colorectal cancer (CRC) in young patients is not an uncommon disease. Reports on its behaviour in young patients are conflicting. The aim of this study was to investigate patient and tumour characteristics, treatment and prognosis of this disease. Methods: Our study group comprised all patients under the age of 40 years treated with CRC at the Department of Surgery at Motol University Hospital in Prague between the years 2005 and 2015. Results: Thirty-eight patients under 40 years of age diagnosed with CRC were included in the study. Five patients had Lynch syndrome and six had first-degree relatives with CRC. There were 22 rectal tumours. All but four patients underwent resection of the primary tumour, all patients received chemotherapy and 13 patients received biological therapy. Disease recurrence occurred in 25.8%. Five-year survival was 47.9%. Advanced disease and adverse histological subtypes were identified as poor prognostic factors. Conclusions: Colorectal cancer in young patients has a high incidence of predisposing conditions, aggressive histological features and advanced disease. Young patients are of a good state of health and thus should receive aggressive therapy. Clinicians should pay more attention to symptoms of CRC in young patients to be able to initiate early treatment.
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