| SLONKOVÁ, Veronika, Veronika Jr. SLONKOVÁ, Anna VAŠKŮ and Vladimír VAŠKŮ. Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. Journal of the European Academy of Dermatovenereology. Hoboken: Wiley-Blackwell, 2017, vol. 31, No 10, p. 1746-1752. ISSN 0926-9959. Available from: https://dx.doi.org/10.1111/jdv.14447. |
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@article{1405510,
author = {Slonková, Veronika and Slonková, Veronika Jr. and Vašků, Anna and Vašků, Vladimír},
article_location = {Hoboken},
article_number = {10},
doi = {http://dx.doi.org/10.1111/jdv.14447},
keywords = {Venous insufficiency; MMP; TIMP},
language = {eng},
issn = {0926-9959},
journal = {Journal of the European Academy of Dermatovenereology},
title = {Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2},
volume = {31},
year = {2017}
}
TY - JOUR
ID - 1405510
AU - Slonková, Veronika - Slonková, Veronika Jr. - Vašků, Anna - Vašků, Vladimír
PY - 2017
TI - Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2
JF - Journal of the European Academy of Dermatovenereology
VL - 31
IS - 10
SP - 1746-1752
EP - 1746-1752
PB - Wiley-Blackwell
SN - 09269959
KW - Venous insufficiency
KW - MMP
KW - TIMP
N2 - OBJECTIVE: The project was scheduled as a case-control study to investigate the correlation between MMP-2 (rs243864), MMP-9 (3918242), MMP-12 (rs7123600) and TIMP-2 (rs8176329) polymorphisms and chronic venous disease (CVD) risk. The genotype and phenotype research envisages the testing of possible associations between MMP and TIMP-2 genotypes and phenotypes of CVD. MATERIAL AND METHODS: 150 patients with CVD and 227 controls were enrolled into the study. The MMPs and TIMP-2 genotypes were identified by the PCR method and restriction analysis according to standard protocols. RESULTS: The G allele of MMP-2 -790 T/G was 1.85 times more frequent in men with CVD than in the control group (P = 0.008). The T allele of MMP-9 -1562 C/T was observed 2.571 times more frequently in patients with CVD than in the control individuals (both in men and women) with clinically significant specificity (P = 0.0000009). The G allele of MMP-12 rs7123600 was determined 2.082 times more frequently in female patients with CVD than in the control group with clinically significant specificity (P = 0.02). No significant result in TIMP-2 rs8176329 polymorphism in the case-control study was observed. CVD women with G allele in MMP-2 -790 T/G in the genotype-phenotype study are seen to develop ulceration 2.539 times more frequently (P = 0.003). The G allele of MMP-12 rs7123600 was detected 3.167 times more frequently in CVD women with ulceration compared with CVD women without ulceration (P = 0.007). In CVD men in C6 stage, the incidence of AG genotype in rs7123600 MMP-12 polymorphism was found to be 4.675 times higher compared to CVD women with C6 staging (P = 0.005). The AG genotype in TIMP 2 rs8176329 polymorphism was found to be associated with higher risk of tumour (P = 0.01). CONCLUSION: Studying these polymorphisms can contribute to better identification of patients at higher risk of developing CVD, while providing the most appropriate prevention and treatment strategies.
ER -
SLONKOVÁ, Veronika, Veronika Jr. SLONKOVÁ, Anna VAŠKŮ and Vladimír VAŠKŮ. Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. \textit{Journal of the European Academy of Dermatovenereology}. Hoboken: Wiley-Blackwell, 2017, vol.~31, No~10, p.~1746-1752. ISSN~0926-9959. Available from: https://dx.doi.org/10.1111/jdv.14447.
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