J 2017

Chronic inflammation in immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?

SUSHAMA JOSE, Shyam, K. BENDICKOVA, Tomáš KEPÁK, Zdenka KŘENOVÁ, J. FRIC et. al.

Basic information

Original name

Chronic inflammation in immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?

Authors

SUSHAMA JOSE, Shyam (356 India, guarantor, belonging to the institution), K. BENDICKOVA (203 Czech Republic), Tomáš KEPÁK (203 Czech Republic), Zdenka KŘENOVÁ (203 Czech Republic) and J. FRIC (203 Czech Republic)

Edition

Frontiers in Immunology, LAUSANNE, FRONTIERS MEDIA SA, 2017, 1664-3224

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.511

RIV identification code

RIV/00216224:14110/17:00099687

Organization unit

Faculty of Medicine

DOI

UT WoS

000409062200001

Keywords in English

pattern recognition receptor signaling; telomere shortening; inflammaging; myelopoiesis; NF-kappa B; toll-like receptor signaling

Tags

International impact, Reviewed
Změněno: 2/3/2018 13:27, Soňa Böhmová

Abstract

V originále

Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely correlated with telomere length in a range of major pathologies. The current review discusses the impact of inflammation on immune aging, the likely molecular mediators of this process, and the various disease states that have been linked with immunosenescence. Emerging findings implicate NF-kappa B, the major driver of inflammatory signaling, in several processes that regulate telomere maintenance and/or telomerase activity. While prolonged triggering of pattern recognition receptors is now known to promote immunosenescence, it remains unclear how this process is linked with the telomere complex or telomerase activity. Indeed, enzymatic control of telomere length has been studied for many decades, but alternative roles of telomerase and potential influences on inflammatory responses are only now beginning to emerge. Crosstalk between these pathways may prove to be a key molecular mechanism of immunosenescence. Understanding how components of immune aging interact and modify host protection against pathogens and tumors will be essential for the design of new vaccines and therapies for a wide range of clinical scenarios.