Detailed Information on Publication Record
2017
Chronic inflammation in immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
SUSHAMA JOSE, Shyam, K. BENDICKOVA, Tomáš KEPÁK, Zdenka KŘENOVÁ, J. FRIC et. al.Basic information
Original name
Chronic inflammation in immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
Authors
SUSHAMA JOSE, Shyam (356 India, guarantor, belonging to the institution), K. BENDICKOVA (203 Czech Republic), Tomáš KEPÁK (203 Czech Republic), Zdenka KŘENOVÁ (203 Czech Republic) and J. FRIC (203 Czech Republic)
Edition
Frontiers in Immunology, LAUSANNE, FRONTIERS MEDIA SA, 2017, 1664-3224
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30102 Immunology
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 5.511
RIV identification code
RIV/00216224:14110/17:00099687
Organization unit
Faculty of Medicine
UT WoS
000409062200001
Keywords in English
pattern recognition receptor signaling; telomere shortening; inflammaging; myelopoiesis; NF-kappa B; toll-like receptor signaling
Tags
International impact, Reviewed
Změněno: 2/3/2018 13:27, Soňa Böhmová
Abstract
V originále
Age-related decline in immunity is characterized by stem cell exhaustion, telomere shortening, and disruption of cell-to-cell communication, leading to increased patient risk of disease. Recent data have demonstrated that chronic inflammation exerts a strong influence on immune aging and is closely correlated with telomere length in a range of major pathologies. The current review discusses the impact of inflammation on immune aging, the likely molecular mediators of this process, and the various disease states that have been linked with immunosenescence. Emerging findings implicate NF-kappa B, the major driver of inflammatory signaling, in several processes that regulate telomere maintenance and/or telomerase activity. While prolonged triggering of pattern recognition receptors is now known to promote immunosenescence, it remains unclear how this process is linked with the telomere complex or telomerase activity. Indeed, enzymatic control of telomere length has been studied for many decades, but alternative roles of telomerase and potential influences on inflammatory responses are only now beginning to emerge. Crosstalk between these pathways may prove to be a key molecular mechanism of immunosenescence. Understanding how components of immune aging interact and modify host protection against pathogens and tumors will be essential for the design of new vaccines and therapies for a wide range of clinical scenarios.