Detailed Information on Publication Record
2018
Irreversible electroporation ablation for atrial fibrillation
WOJTASZCZYK, Adam, Guido CALUORI, Martin PEŠL, Katarína MELAJOVÁ, Zdeněk STÁREK et. al.Basic information
Original name
Irreversible electroporation ablation for atrial fibrillation
Authors
WOJTASZCZYK, Adam (616 Poland), Guido CALUORI (380 Italy, belonging to the institution), Martin PEŠL (203 Czech Republic, belonging to the institution), Katarína MELAJOVÁ (703 Slovakia, belonging to the institution) and Zdeněk STÁREK (203 Czech Republic, guarantor, belonging to the institution)
Edition
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, HOBOKEN, WILEY, 2018, 1045-3873
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.910
RIV identification code
RIV/00216224:14110/18:00102244
Organization unit
Faculty of Medicine
UT WoS
000430109200023
Keywords in English
atrial fibrillation; fibrosis; irreversible electroporation; nonthermal ablation; pulmonary vein isolation
Tags
International impact, Reviewed
Změněno: 12/3/2019 12:25, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
Atrial fibrillation (AF) is one of the most important problems in modern cardiology. Thermal ablation therapies, especially radiofrequency ablation (RF), are currently "gold standard" to treat symptomatic AF by localized tissue necrosis. Despite the improvements in reestablishing sinus rhythm using available methods, both success rate and safety are limited by the thermal nature of procedures. Thus, while keeping the technique in clinical practice, safer and more versatile methods of removing abnormal tissue are being investigated. This review focuses on irreversible electroporation (IRE), a nonthermal ablation method, which is based on the unrecoverable permeabilization of cell membranes caused by short pulses of high voltage/current. While still in its preclinical steps for what concerns interventional cardiac electrophysiology, multiple studies have shown the efficacy of this method on animal models. The observed remodeling process shows this technique as tissue specific, triggering apoptosis rather than necrosis, and safer for the structures adjacent the myocardium. So far, proposed IRE methodologies are heterogeneous. The number of devices (both generators and applicators), techniques, and therapeutic goals impair the comparability of performed studies. More questions regarding systemic safety and optimal processes for AF treatment remain to be answered. This work provides an overview of the electroporation process, and presents different results obtained by cardiology-oriented research groups that employ IRE ablation, with focus of AF-related targets. This contribution on the topic aspires to be a practical guide to approach IRE ablation for cardiac arrhythmias, and to highlight controversial features and existing knowledge, to provide background for future improved experimentation with IRE in arrhythmology.
Links
| MUNI/A/1010/2016, interní kód MU |
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