| BOSTROM, Johan, Zuzana ŠRÁMKOVÁ, Alena SALAŠOVÁ, Helena Anna Dagmar JOHARD, Diana MAHDESSIAN, Radek FEDR, Carolyn MARKS, Jiřina MEDALOVÁ, Karel SOUČEK, Emma LUNDBERG, Sten LINNARSON, Vítězslav BRYJA, Petra SEKYROVÁ, Mikael ALTUN and Michael ANDÄNG. Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells. PLOS ONE. Public Library of Science, 2017, vol. 12, No 12, p. 0188772-188795. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0188772. |
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@article{1405981,
author = {Bostrom, Johan and Šrámková, Zuzana and Salašová, Alena and Johard, Helena Anna Dagmar and Mahdessian, Diana and Fedr, Radek and Marks, Carolyn and Medalová, Jiřina and Souček, Karel and Lundberg, Emma and Linnarson, Sten and Bryja, Vítězslav and Sekyrová, Petra and Altun, Mikael and Andäng, Michael},
article_number = {12},
doi = {http://dx.doi.org/10.1371/journal.pone.0188772},
keywords = {cell cycle; synchronization; fucci reporter},
language = {eng},
issn = {1932-6203},
journal = {PLOS ONE},
title = {Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724894/pdf/pone.0188772.pdf},
volume = {12},
year = {2017}
}
TY - JOUR
ID - 1405981
AU - Bostrom, Johan - Šrámková, Zuzana - Salašová, Alena - Johard, Helena Anna Dagmar - Mahdessian, Diana - Fedr, Radek - Marks, Carolyn - Medalová, Jiřina - Souček, Karel - Lundberg, Emma - Linnarson, Sten - Bryja, Vítězslav - Sekyrová, Petra - Altun, Mikael - Andäng, Michael
PY - 2017
TI - Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells
JF - PLOS ONE
VL - 12
IS - 12
SP - 0188772
EP - 0188772
PB - Public Library of Science
SN - 19326203
KW - cell cycle
KW - synchronization
KW - fucci reporter
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724894/pdf/pone.0188772.pdf
L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724894/pdf/pone.0188772.pdf
N2 - The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated transcription in the control of non-core functions, such as cell identity maintenance through specific transcription factors (TFs) and signalling pathways remains unclear. Here, we provide a resource consisting of mapped transcriptomes in unsynchronized HeLa and U2OS cancer cells sorted for cell cycle phase by Fucci reporter expression. We developed a novel algorithm for data analysis that enables efficient visualization and data comparisons and identified cell cycle synchronization of Notch signalling and TFs associated with development. Furthermore, the cell cycle synchronizes with the circadian clock, providing a possible link between developmental transcriptional networks and the cell cycle. In conclusion we find that cell cycle synchronized transcriptional patterns are temporally compartmentalized and more complex than previously anticipated, involving genes, which control cell identity and development.
ER -
BOSTROM, Johan, Zuzana ŠRÁMKOVÁ, Alena SALAŠOVÁ, Helena Anna Dagmar JOHARD, Diana MAHDESSIAN, Radek FEDR, Carolyn MARKS, Jiřina MEDALOVÁ, Karel SOUČEK, Emma LUNDBERG, Sten LINNARSON, Vítězslav BRYJA, Petra SEKYROVÁ, Mikael ALTUN and Michael ANDÄNG. Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells. \textit{PLOS ONE}. Public Library of Science, 2017, vol.~12, No~12, p.~0188772-188795. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0188772.
|
