J 2016

BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner

CELÁ, Petra, marcela BUCHTOVÁ, Iva VESELÁ, Cathy FU, Jean-Philippe BOGARDI et. al.

Basic information

Original name

BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner

Authors

CELÁ, Petra (203 Czech Republic, belonging to the institution), marcela BUCHTOVÁ (203 Czech Republic, guarantor, belonging to the institution), Iva VESELÁ (203 Czech Republic), Cathy FU (124 Canada), Jean-Philippe BOGARDI (124 Canada), Yiping SONG (124 Canada), Amanda BARLOW (124 Canada), Paul BUXTON (124 Canada), Jiřina MEDALOVÁ (203 Czech Republic), Philippa FRANCIS-WEST (124 Canada) and Joy M. RICHMAN (124 Canada)

Edition

DEVELOPMENTAL DYNAMICS, Hoboken, NJ USA, WILEY-BLACKWELL, 2016, 1058-8388

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10605 Developmental biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.004

RIV identification code

RIV/00216224:14310/16:00099784

Organization unit

Faculty of Science

DOI

UT WoS

000384752100005

Keywords in English

BMP; chick embryo; Chondro-osteoprogenitor Cells ; facial development

Tags

Změněno: 13/4/2018 12:49, Ing. Nicole Zrilić

Abstract

V originále

Lineage tracing has shown that most of the facial skeleton is derived from cranial neural crest cells. However, the local signals that influence postmigratory, neural crest-derived mesenchyme also play a major role in patterning the skeleton. Here, we study the role of BMP signaling in regulating the fate of chondro-osteoprogenitor cells in the face. A single Noggin-soaked bead inserted into stage 15 chicken embryos induced an ectopic cartilage resembling the interorbital septum within the palate and other midline structures. In contrast, the same treatment in stage 20 embryos caused a loss of bones. The molecular basis for the stage-specific response to Noggin lay in the simultaneous up-regulation of SOX9 and downregulation of RUNX2 in the maxillary mesenchyme, increased cell adhesiveness as shown by N-cadherin induction around the beads and increased RA pathway gene expression. None of these changes were observed in stage 20 embryos.These experiments demonstrate how slight changes in expression of growth factors such as BMPs could lead to gain or loss of cartilage in the upper jaw during vertebrate evolution. In addition, BMPs have at least two roles: one in patterning the skull and another in regulating the skeletogenic fates of neural crest-derived mesenchyme.