| CELÁ, Petra, marcela BUCHTOVÁ, Iva VESELÁ, Cathy FU, Jean-Philippe BOGARDI, Yiping SONG, Amanda BARLOW, Paul BUXTON, Jiřina MEDALOVÁ, Philippa FRANCIS-WEST and Joy M. RICHMAN. BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner. DEVELOPMENTAL DYNAMICS. Hoboken, NJ USA: WILEY-BLACKWELL, 2016, vol. 245, No 9, p. 947-962. ISSN 1058-8388. Available from: https://dx.doi.org/10.1002/DVDY.24422. |
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@article{1405989,
author = {Celá, Petra and Buchtová, marcela and Veselá, Iva and Fu, Cathy and Bogardi, JeanandPhilippe and Song, Yiping and Barlow, Amanda and Buxton, Paul and Medalová, Jiřina and FrancisandWest, Philippa and Richman, Joy M.},
article_location = {Hoboken, NJ USA},
article_number = {9},
doi = {http://dx.doi.org/10.1002/DVDY.24422},
keywords = {BMP; chick embryo; Chondro-osteoprogenitor Cells ; facial development},
language = {eng},
issn = {1058-8388},
journal = {DEVELOPMENTAL DYNAMICS},
title = {BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner},
url = {http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/pdf},
volume = {245},
year = {2016}
}
TY - JOUR
ID - 1405989
AU - Celá, Petra - Buchtová, marcela - Veselá, Iva - Fu, Cathy - Bogardi, Jean-Philippe - Song, Yiping - Barlow, Amanda - Buxton, Paul - Medalová, Jiřina - Francis-West, Philippa - Richman, Joy M.
PY - 2016
TI - BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner
JF - DEVELOPMENTAL DYNAMICS
VL - 245
IS - 9
SP - 947-962
EP - 947-962
PB - WILEY-BLACKWELL
SN - 10588388
KW - BMP
KW - chick embryo
KW - Chondro-osteoprogenitor Cells
KW - facial development
UR - http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/pdf
L2 - http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/pdf
N2 - Lineage tracing has shown that most of the facial skeleton is derived from cranial neural crest cells. However, the local signals that influence postmigratory, neural crest-derived mesenchyme also play a major role in patterning the skeleton. Here, we study the role of BMP signaling in regulating the fate of chondro-osteoprogenitor cells in the face. A single Noggin-soaked bead inserted into stage 15 chicken embryos induced an ectopic cartilage resembling the interorbital septum within the palate and other midline structures. In contrast, the same treatment in stage 20 embryos caused a loss of bones. The molecular basis for the stage-specific response to Noggin lay in the simultaneous up-regulation of SOX9 and downregulation of RUNX2 in the maxillary mesenchyme, increased cell adhesiveness as shown by N-cadherin induction around the beads and increased RA pathway gene expression. None of these changes were observed in stage 20 embryos.These experiments demonstrate how slight changes in expression of growth factors such as BMPs could lead to gain or loss of cartilage in the upper jaw during vertebrate evolution. In addition, BMPs have at least two roles: one in patterning the skull and another in regulating the skeletogenic fates of neural crest-derived mesenchyme.
ER -
CELÁ, Petra, marcela BUCHTOVÁ, Iva VESELÁ, Cathy FU, Jean-Philippe BOGARDI, Yiping SONG, Amanda BARLOW, Paul BUXTON, Jiřina MEDALOVÁ, Philippa FRANCIS-WEST and Joy M. RICHMAN. BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner. \textit{DEVELOPMENTAL DYNAMICS}. Hoboken, NJ USA: WILEY-BLACKWELL, 2016, vol.~245, No~9, p.~947-962. ISSN~1058-8388. Available from: https://dx.doi.org/10.1002/DVDY.24422.
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