WNT signaling pathways in chronic lymphocytic leukemia and B
cell lymphomas

J 2017

WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas

JANOVSKÁ, Pavlína and Vítězslav BRYJA

Basic information

Original name

WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas

Authors

JANOVSKÁ, Pavlína (203 Czech Republic, belonging to the institution) and Vítězslav BRYJA (203 Czech Republic, guarantor, belonging to the institution)

Edition

BRITISH JOURNAL OF PHARMACOLOGY, Hoboken, WILEY, 2017, 0007-1188

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 6.810

RIV identification code

RIV/00216224:14310/17:00095705

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1111/bph.13949

UT WoS

000427839000012

Keywords in English

LONG NONCODING RNA; WNT/BETA-CATENIN PATHWAY; EPITHELIAL-MESENCHYMAL TRANSITION; OVARIAN-CANCER CELLS; MOUSE SPERMATOGONIAL CELLS; REGULATE GENE-EXPRESSION; PROSTATE-SPECIFIC GENE; STEM-LIKE CELLS; BREAST-CANCER; CERVICAL-CANCER

Abstract

V originále

In this review, we discuss the intricate roles of the Wnt signalling network in the development and progression of mature B-cell-derived haematological malignancies, with a focus on chronic lymphocytic leukaemia (CLL) and related B-cell lymphomas. We review the current literature and highlight the differences between the beta-catenin-dependent and -independent branches of Wnt signalling. Special attention is paid to the role of the non-canonical Wnt/planar cell polarity (PCP) pathway, mediated by the Wnt-5-receptor tyrosine kinase-like orphan receptor (ROR1)-Dishevelled signalling axis in CLL. This is mainly because the Wnt/PCP co-receptor ROR1 was found to be overexpressed in CLL and the Wnt/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutically targeting the Wnt signalling pathways as an approach to disrupt the crucial interaction between malignant cells and their micro-environment. We also advocate the need for research in this direction for other lymphomas, namely, diffuse large B-cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma and follicular lymphoma where the Wnt signalling pathway probably plays a similar role.

Links

NV15-29793A, research and development project

Name: Analýza Wnt/PCP jako nástroj pro lepší management chronické lymfocytární leukémie

Citovat

JANOVSKÁ, Pavlína and Vítězslav BRYJA. WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas. BRITISH JOURNAL OF PHARMACOLOGY. Hoboken: WILEY, 2017, vol. 174, No 24, p. 4701-4715. ISSN 0007-1188. Available from: https://dx.doi.org/10.1111/bph.13949.

@article{1406114,
   author = {Janovská, Pavlína and Bryja, Vítězslav},
   article_location = {Hoboken},
   article_number = {24},
   doi = {http://dx.doi.org/10.1111/bph.13949},
   keywords = {LONG NONCODING RNA; WNT/BETA-CATENIN PATHWAY; EPITHELIAL-MESENCHYMAL TRANSITION; OVARIAN-CANCER CELLS; MOUSE SPERMATOGONIAL CELLS; REGULATE GENE-EXPRESSION; PROSTATE-SPECIFIC GENE; STEM-LIKE CELLS; BREAST-CANCER; CERVICAL-CANCER},
   language = {eng},
   issn = {0007-1188},
   journal = {BRITISH JOURNAL OF PHARMACOLOGY},
   title = {WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas},
   volume = {174},
   year = {2017}
}

TY  - JOUR
ID  - 1406114
AU  - Janovská, Pavlína - Bryja, Vítězslav
PY  - 2017
TI  - WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas
JF  - BRITISH JOURNAL OF PHARMACOLOGY
VL  - 174
IS  - 24
SP  - 4701-4715
EP  - 4701-4715
PB  - WILEY
SN  - 00071188
KW  - LONG NONCODING RNA
KW  - WNT/BETA-CATENIN PATHWAY
KW  - EPITHELIAL-MESENCHYMAL TRANSITION
KW  - OVARIAN-CANCER CELLS
KW  - MOUSE SPERMATOGONIAL CELLS
KW  - REGULATE GENE-EXPRESSION
KW  - PROSTATE-SPECIFIC GENE
KW  - STEM-LIKE CELLS
KW  - BREAST-CANCER
KW  - CERVICAL-CANCER
N2  - In this review, we discuss the intricate roles of the Wnt signalling network in the development and progression of mature B-cell-derived haematological malignancies, with a focus on chronic lymphocytic leukaemia (CLL) and related B-cell lymphomas. We review the current literature and highlight the differences between the beta-catenin-dependent and -independent branches of Wnt signalling. Special attention is paid to the role of the non-canonical Wnt/planar cell polarity (PCP) pathway, mediated by the Wnt-5-receptor tyrosine kinase-like orphan receptor (ROR1)-Dishevelled signalling axis in CLL. This is mainly because the Wnt/PCP co-receptor ROR1 was found to be overexpressed in CLL and the Wnt/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutically targeting the Wnt signalling pathways as an approach to disrupt the crucial interaction between malignant cells and their micro-environment. We also advocate the need for research in this direction for other lymphomas, namely, diffuse large B-cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma and follicular lymphoma where the Wnt signalling pathway probably plays a similar role.
ER  -

JANOVSKÁ, Pavlína and Vítězslav BRYJA. WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas. \textit{BRITISH JOURNAL OF PHARMACOLOGY}. Hoboken: WILEY, 2017, vol.~174, No~24, p.~4701-4715. ISSN~0007-1188. Available from: https://dx.doi.org/10.1111/bph.13949.

Detailed Information on Publication Record