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@article{1406114,
author = {Janovská, Pavlína and Bryja, Vítězslav},
article_location = {Hoboken},
article_number = {24},
doi = {http://dx.doi.org/10.1111/bph.13949},
keywords = {LONG NONCODING RNA; WNT/BETA-CATENIN PATHWAY; EPITHELIAL-MESENCHYMAL TRANSITION; OVARIAN-CANCER CELLS; MOUSE SPERMATOGONIAL CELLS; REGULATE GENE-EXPRESSION; PROSTATE-SPECIFIC GENE; STEM-LIKE CELLS; BREAST-CANCER; CERVICAL-CANCER},
language = {eng},
issn = {0007-1188},
journal = {BRITISH JOURNAL OF PHARMACOLOGY},
title = {WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas},
volume = {174},
year = {2017}
}
TY - JOUR
ID - 1406114
AU - Janovská, Pavlína - Bryja, Vítězslav
PY - 2017
TI - WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas
JF - BRITISH JOURNAL OF PHARMACOLOGY
VL - 174
IS - 24
SP - 4701-4715
EP - 4701-4715
PB - WILEY
SN - 00071188
KW - LONG NONCODING RNA
KW - WNT/BETA-CATENIN PATHWAY
KW - EPITHELIAL-MESENCHYMAL TRANSITION
KW - OVARIAN-CANCER CELLS
KW - MOUSE SPERMATOGONIAL CELLS
KW - REGULATE GENE-EXPRESSION
KW - PROSTATE-SPECIFIC GENE
KW - STEM-LIKE CELLS
KW - BREAST-CANCER
KW - CERVICAL-CANCER
N2 - In this review, we discuss the intricate roles of the Wnt signalling network in the development and progression of mature B-cell-derived haematological malignancies, with a focus on chronic lymphocytic leukaemia (CLL) and related B-cell lymphomas. We review the current literature and highlight the differences between the beta-catenin-dependent and -independent branches of Wnt signalling. Special attention is paid to the role of the non-canonical Wnt/planar cell polarity (PCP) pathway, mediated by the Wnt-5-receptor tyrosine kinase-like orphan receptor (ROR1)-Dishevelled signalling axis in CLL. This is mainly because the Wnt/PCP co-receptor ROR1 was found to be overexpressed in CLL and the Wnt/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutically targeting the Wnt signalling pathways as an approach to disrupt the crucial interaction between malignant cells and their micro-environment. We also advocate the need for research in this direction for other lymphomas, namely, diffuse large B-cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma and follicular lymphoma where the Wnt signalling pathway probably plays a similar role.
ER -
JANOVSKÁ, Pavlína and Vítězslav BRYJA. WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas. \textit{BRITISH JOURNAL OF PHARMACOLOGY}. Hoboken: WILEY, 2017, vol.~174, No~24, p.~4701-4715. ISSN~0007-1188. Available from: https://dx.doi.org/10.1111/bph.13949.
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