CD36 gene polymorphism is associated with Alzheimer's disease

J 2017

CD36 gene polymorphism is associated with Alzheimer's disease

ŠERÝ, Omar, J. JANOUTOVA, Laura EWERLINGOVÁ, Alice HÁLOVÁ, Jan LOCHMAN et. al.

Basic information

Original name

CD36 gene polymorphism is associated with Alzheimer's disease

Authors

ŠERÝ, Omar (203 Czech Republic, guarantor, belonging to the institution), J. JANOUTOVA (203 Czech Republic), Laura EWERLINGOVÁ (203 Czech Republic, belonging to the institution), Alice HÁLOVÁ (203 Czech Republic, belonging to the institution), Jan LOCHMAN (203 Czech Republic, belonging to the institution), Vladimír JANOUT (203 Czech Republic, belonging to the institution), Naim Akhtar KHAN (250 France) and VJ BALCAR (203 Czech Republic)

Edition

Biochimie, Paris, Elsevier France- editions Scientifiques Medicales Elsevier, 2017, 0300-9084

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

France

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.188

RIV identification code

RIV/00216224:14310/17:00095706

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.biochi.2017.01.009

UT WoS

000397694600006

Keywords in English

Polymorphism; Association; CD36; Gene; ApoE; MMSE

Abstract

V originále

CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.

Links

NV16-31207A, research and development project

Name: Genetika a epidemiologie Alzheimerovy choroby

16-31207A, interní kód MU
(CEP code: NV16-31207A)

Name: Genetika a epidemiologie Alzheimerovy choroby (Acronym: Alzheimer)

Investor: Ministry of Health of the CR

Citovat

ŠERÝ, Omar, J. JANOUTOVA, Laura EWERLINGOVÁ, Alice HÁLOVÁ, Jan LOCHMAN, Vladimír JANOUT, Naim Akhtar KHAN and VJ BALCAR. CD36 gene polymorphism is associated with Alzheimer's disease. Biochimie. Paris: Elsevier France- editions Scientifiques Medicales Elsevier, 2017, vol. 135, April, p. 46-53. ISSN 0300-9084. Available from: https://dx.doi.org/10.1016/j.biochi.2017.01.009.

@article{1406153,
   author = {Šerý, Omar and Janoutova, J. and Ewerlingová, Laura and Hálová, Alice and Lochman, Jan and Janout, Vladimír and Khan, Naim Akhtar and Balcar, VJ},
   article_location = {Paris},
   article_number = {April},
   doi = {http://dx.doi.org/10.1016/j.biochi.2017.01.009},
   keywords = {Polymorphism; Association; CD36; Gene; ApoE; MMSE},
   language = {eng},
   issn = {0300-9084},
   journal = {Biochimie},
   title = {CD36 gene polymorphism is associated with Alzheimer's disease},
   volume = {135},
   year = {2017}
}

TY  - JOUR
ID  - 1406153
AU  - Šerý, Omar - Janoutova, J. - Ewerlingová, Laura - Hálová, Alice - Lochman, Jan - Janout, Vladimír - Khan, Naim Akhtar - Balcar, VJ
PY  - 2017
TI  - CD36 gene polymorphism is associated with Alzheimer's disease
JF  - Biochimie
VL  - 135
IS  - April
SP  - 46-53
EP  - 46-53
PB  - Elsevier France- editions Scientifiques Medicales Elsevier
SN  - 03009084
KW  - Polymorphism
KW  - Association
KW  - CD36
KW  - Gene
KW  - ApoE
KW  - MMSE
N2  - CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
ER  -

ŠERÝ, Omar, J. JANOUTOVA, Laura EWERLINGOVÁ, Alice HÁLOVÁ, Jan LOCHMAN, Vladimír JANOUT, Naim Akhtar KHAN and VJ BALCAR. CD36 gene polymorphism is associated with Alzheimer's disease. \textit{Biochimie}. Paris: Elsevier France- editions Scientifiques Medicales Elsevier, 2017, vol.~135, April, p.~46-53. ISSN~0300-9084. Available from: https://dx.doi.org/10.1016/j.biochi.2017.01.009.

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