SVÁTKOVÁ, Alena, Bryon MUELLER, Petr BEDNAŘÍK, Carol NGUYEN, Lubomír VOJTÍŠEK, Silvia MANGIA, Mikko NISSI, Shalom MICHAELI and Igor NESTRAŠIL. Rotating Frame MRI Contrasts For Assessment of White Matter Alteration in Mucopolysaccharidosis Type I. In Joint annual meeting ISMRM-ESMRMB 2018. 2018.
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Basic information
Original name Rotating Frame MRI Contrasts For Assessment of White Matter Alteration in Mucopolysaccharidosis Type I
Name (in English) Rotating Frame MRI Contrasts For Assessment of White Matter Alteration in Mucopolysaccharidosis Type I
Authors SVÁTKOVÁ, Alena, Bryon MUELLER, Petr BEDNAŘÍK, Carol NGUYEN, Lubomír VOJTÍŠEK, Silvia MANGIA, Mikko NISSI, Shalom MICHAELI and Igor NESTRAŠIL.
Edition Joint annual meeting ISMRM-ESMRMB 2018, 2018.
Other information
Type of outcome Conference abstract
Confidentiality degree is not subject to a state or trade secret
Changed by Changed by: MUDr. Petr Bednařík, Ph.D., učo 15260. Changed: 3/2/2018 19:31.
Abstract
Mucopolysaccharidosis type I (MPSI) is an inherited metabolic disease with severe and attenuated disease subtypes. While both MPSI subtypes manifest pronounced morphological brain changes, little has been discovered about alterations of white matter (WM) microstructure. Here, we utilized rotating frame MRI contrasts along with DTI to detect WM alterations in 11 severe and 9 attenuated MPSI patients at 3T. T1ρ and RAFF4 detected WM differences between MPS subtypes that were not depicted by DTI. Outcomes demonstrate an exceptional sensitivity of rotating frame methods to probe WM microstructure in MPSI.
Abstract (in English)
Mucopolysaccharidosis type I (MPSI) is an inherited metabolic disease with severe and attenuated disease subtypes. While both MPSI subtypes manifest pronounced morphological brain changes, little has been discovered about alterations of white matter (WM) microstructure. Here, we utilized rotating frame MRI contrasts along with DTI to detect WM alterations in 11 severe and 9 attenuated MPSI patients at 3T. T1ρ and RAFF4 detected WM differences between MPS subtypes that were not depicted by DTI. Outcomes demonstrate an exceptional sensitivity of rotating frame methods to probe WM microstructure in MPSI.
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