Principles of Diffusion Kurtosis Imaging and its Role in Early
Diagnosis of Neurodegenerative Disorders

J 2018

Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders

ARAB, Anas, Anna WOJNA PELCZAR, Amit Suresh KHAIRNAR, Nikoletta SZABÓ, Jana RUDÁ et. al.

Basic information

Original name

Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders

Name in Czech

Princip Diffusion Kurtosis Imaging a jeho role v časné diagnostice neurodegenerativních onemocnění

Authors

ARAB, Anas (760 Syrian Arab Republic, belonging to the institution), Anna WOJNA PELCZAR (616 Poland, belonging to the institution), Amit Suresh KHAIRNAR (356 India, guarantor), Nikoletta SZABÓ (348 Hungary, belonging to the institution) and Jana RUDÁ (203 Czech Republic, belonging to the institution)

Edition

Brain Research Bulletin, Oxford, Pergamon-Elsevier Science LTD, 2018, 0361-9230

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.103

RIV identification code

RIV/00216224:14110/18:00102274

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.brainresbull.2018.01.015

UT WoS

000433651600011

Keywords in English

Diffusion kurtosis imaging; neuroimaging; neurodegenerative disorders; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease

Abstract

V originále

Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as extracellular changes which lead to neuronal degeneration. The central nervous system (CNS) is a complex structure comprising of many biological barriers. These microstructural barriers might be affected by a variety of pathological processes. Specifically, changes in the brain tissue’s microstructure affect the diffusion of water which can be assessed non-invasively by diffusion weighted (DW) magnetic resonance imaging (MRI) techniques. Hence, the purpose of this article is to summarize the ongoing clinical and preclinical research on Parkinson’s, Alzheimer’s and Huntington diseases, using DKI and to discuss the role of this technique as an early stage biomarker of neurodegenerative conditions.

Links

MUNI/A/1132/2017, interní kód MU

Name: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masaryk University, Category A

Citovat

ARAB, Anas, Anna WOJNA PELCZAR, Amit Suresh KHAIRNAR, Nikoletta SZABÓ and Jana RUDÁ. Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders. Brain Research Bulletin. Oxford: Pergamon-Elsevier Science LTD, 2018, vol. 139, MAY 2018, p. 91-98. ISSN 0361-9230. Available from: https://dx.doi.org/10.1016/j.brainresbull.2018.01.015.

@article{1406888,
   author = {Arab, Anas and Wojna Pelczar, Anna and Khairnar, Amit Suresh and Szabó, Nikoletta and Rudá, Jana},
   article_location = {Oxford},
   article_number = {MAY 2018},
   doi = {http://dx.doi.org/10.1016/j.brainresbull.2018.01.015},
   keywords = {Diffusion kurtosis imaging; neuroimaging; neurodegenerative disorders; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease},
   language = {eng},
   issn = {0361-9230},
   journal = {Brain Research Bulletin},
   title = {Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders},
   volume = {139},
   year = {2018}
}

TY  - JOUR
ID  - 1406888
AU  - Arab, Anas - Wojna Pelczar, Anna - Khairnar, Amit Suresh - Szabó, Nikoletta - Rudá, Jana
PY  - 2018
TI  - Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders
JF  - Brain Research Bulletin
VL  - 139
IS  - MAY 2018
SP  - 91-98
EP  - 91-98
PB  - Pergamon-Elsevier Science LTD
SN  - 03619230
KW  - Diffusion kurtosis imaging
KW  - neuroimaging
KW  - neurodegenerative disorders
KW  - Parkinson’s disease
KW  - Alzheimer’s disease
KW  - Huntington’s disease
N2  - Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as extracellular changes which lead to neuronal degeneration. The central nervous system (CNS) is a complex structure comprising of many biological barriers. These microstructural barriers might be affected by a variety of pathological processes. Specifically, changes in the brain tissue’s microstructure affect the diffusion of water which can be assessed non-invasively by diffusion weighted (DW) magnetic resonance imaging (MRI) techniques. Hence, the purpose of this article is to summarize the ongoing clinical and preclinical research on Parkinson’s, Alzheimer’s and Huntington diseases, using DKI and to discuss the role of this technique as an early stage biomarker of neurodegenerative conditions.
ER  -

ARAB, Anas, Anna WOJNA PELCZAR, Amit Suresh KHAIRNAR, Nikoletta SZABÓ and Jana RUDÁ. Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders. \textit{Brain Research Bulletin}. Oxford: Pergamon-Elsevier Science LTD, 2018, vol.~139, MAY 2018, p.~91-98. ISSN~0361-9230. Available from: https://dx.doi.org/10.1016/j.brainresbull.2018.01.015.

Detailed Information on Publication Record