| LEHERICY, S., D.E. VAILLANCOURT, K. SEPPI, O. MONCHI, Irena REKTOROVÁ, A. ANTONINI, M.J. MCKEOWN, M. MASELLIS, D. BERG, J.B. ROWE, S.J.G. LEWIS, C.H. WILLIAMS-GRAY, A. TESSITORE a H.R. SIEBNER. The Role of High-Field Magnetic Resonance Imaging in Parkinsonian Disorders: Pushing the Boundaries Forward. Movement Disorders. HOBOKEN: WILEY, roč. 32, č. 4, s. 510-525. ISSN 0885-3185. doi:10.1002/mds.26968. 2017. |
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@article{1406922,
author = {Lehericy, S. and Vaillancourt, D.E. and Seppi, K. and Monchi, O. and Rektorová, Irena and Antonini, A. and McKeown, M.J. and Masellis, M. and Berg, D. and Rowe, J.B. and Lewis, S.J.G. and WilliamsandGray, C.H. and Tessitore, A. and Siebner, H.R.},
article_location = {HOBOKEN},
article_number = {4},
doi = {http://dx.doi.org/10.1002/mds.26968},
keywords = {Parkinson's disease; atypical parkinsonism; MRI; iron; neuromelanin; diffusion MRI; fMRI; resting state fMRI; 7T},
language = {eng},
issn = {0885-3185},
journal = {Movement Disorders},
title = {The Role of High-Field Magnetic Resonance Imaging in Parkinsonian Disorders: Pushing the Boundaries Forward},
volume = {32},
year = {2017}
}
TY - JOUR
ID - 1406922
AU - Lehericy, S. - Vaillancourt, D.E. - Seppi, K. - Monchi, O. - Rektorová, Irena - Antonini, A. - McKeown, M.J. - Masellis, M. - Berg, D. - Rowe, J.B. - Lewis, S.J.G. - Williams-Gray, C.H. - Tessitore, A. - Siebner, H.R.
PY - 2017
TI - The Role of High-Field Magnetic Resonance Imaging in Parkinsonian Disorders: Pushing the Boundaries Forward
JF - Movement Disorders
VL - 32
IS - 4
SP - 510-525
EP - 510-525
PB - WILEY
SN - 08853185
KW - Parkinson's disease
KW - atypical parkinsonism
KW - MRI
KW - iron
KW - neuromelanin
KW - diffusion MRI
KW - fMRI
KW - resting state fMRI
KW - 7T
N2 - Historically, magnetic resonance imaging (MRI) has contributed little to the study of Parkinson's disease (PD), but modern MRI approaches have unveiled several complementary markers that are useful for research and clinical applications. Iron- and neuromelanin-sensitive MRI detect qualitative changes in the substantia nigra. Quantitative MRI markers can be derived from diffusion weighted and iron-sensitive imaging or volumetry. Functional brain alterations at rest or during task performance have been captured with functional and arterial spin labeling perfusion MRI. These markers are useful for the diagnosis of PD and atypical parkinsonism, to track disease progression from the premotor stages of these diseases and to better understand the neurobiological basis of clinical deficits. A current research goal using MRI is to generate time-dependent models of the evolution of PD biomarkers that can help understand neurodegeneration and provide reliable markers for therapeutic trials. This article reviews recent advances in MRI biomarker research at high-field (3T) and ultra high field-imaging (7T) in PD and atypical parkinsonism. (c) 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
ER -
LEHERICY, S., D.E. VAILLANCOURT, K. SEPPI, O. MONCHI, Irena REKTOROVÁ, A. ANTONINI, M.J. MCKEOWN, M. MASELLIS, D. BERG, J.B. ROWE, S.J.G. LEWIS, C.H. WILLIAMS-GRAY, A. TESSITORE a H.R. SIEBNER. The Role of High-Field Magnetic Resonance Imaging in Parkinsonian Disorders: Pushing the Boundaries Forward. \textit{Movement Disorders}. HOBOKEN: WILEY, roč.~32, č.~4, s.~510-525. ISSN~0885-3185. doi:10.1002/mds.26968. 2017.
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