LOBELLO, Cosimo, Andrea JANÍKOVÁ, Leoš KŘEN, Markéta HERMANOVÁ, Andrea ŠPRLÁKOVÁ-PUKOVÁ, Jan KREJČÍ, Šárka POSPÍŠILOVÁ, Robert PYTLÍK, Michaela HAMOUZOVÁ, David BELADA, Vit PROCHAZKA, Juraj DURAS, Heidi MÓCIKOVÁ and Marek TRNĚNÝ. An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed nonHodgkin’s lymphoma from the Czech Lymphoma Study Group (CLSG) database (An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin's lymphoma from the Czech Lymphoma Study Group (CLSG) database). Journal of Cancer Research & Therapy. Manchester: NobleResearch Publishers Limited, 2017, vol. 5, No 10, p. 66-71. ISSN 2052-4994. Available from: https://dx.doi.org/10.14312/2052-4994.2017-13.
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Basic information
Original name An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed nonHodgkin’s lymphoma from the Czech Lymphoma Study Group (CLSG) database
Authors LOBELLO, Cosimo (380 Italy, belonging to the institution), Andrea JANÍKOVÁ (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Czech Republic), Jan KREJČÍ (203 Czech Republic), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Robert PYTLÍK (203 Czech Republic), Michaela HAMOUZOVÁ (203 Czech Republic), David BELADA (203 Czech Republic), Vit PROCHAZKA (203 Czech Republic), Juraj DURAS (203 Czech Republic), Heidi MÓCIKOVÁ (203 Czech Republic) and Marek TRNĚNÝ (203 Czech Republic).
Edition Journal of Cancer Research & Therapy, Manchester, NobleResearch Publishers Limited, 2017, 2052-4994.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14110/17:00099922
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.14312/2052-4994.2017-13
Keywords in English cardiac lymphoma; anaplastic large cell lymphoma; ALK
Tags EL OK
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 6/3/2018 15:46.
Abstract
We report a rare case of anaplastic large cell ALK+ lymphoma (ALCL) with initial asymptomatic cardiac involvement. A 59-year-old male with infiltration of the right ventricular wall underwent standard combined chemotherapy (CHOP) and achieved remission without significant cardiac impairment. Additionally, we report the actual incidence of cardiac lymphoma in newly diagnosed non-Hodgkin Lymphomas (NHLs). In total, 16 patients with cardiac lymphoma were found (0.1% NHLs) in the Czech Lymphoma Study Group database. DLBCL was the most frequent histology subtype (50%), and ALCL was identified in 12.5% of cases. At initial diagnosis, the median age was 55.5 (range 21-74) years and 59% were men. None of the 16 patients with cardiac involvement had isolated heart lymphoma. The response to first-line therapy was 79% in 14/16 evaluable patients. The median progression-free survival and overall survival were nearly the same -approximately 3.5 years (range; 0.05-16.7ys), while the median follow up was 4 years.
Links
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
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