J 2018

Effect of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger

KUSHKEVYCH, Ivan, Monika VÍTĚZOVÁ, Jiri KOS, Peter KOLLÁR, Josef JAMPI­LEK et. al.

Basic information

Original name

Effect of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger

Authors

KUSHKEVYCH, Ivan (804 Ukraine, belonging to the institution), Monika VÍTĚZOVÁ (203 Czech Republic, belonging to the institution), Jiri KOS (203 Czech Republic), Peter KOLLÁR (203 Czech Republic) and Josef JAMPI­LEK (203 Czech Republic)

Edition

Journal of Applied Biomedicine, Jihočeská univerzita v Českých Budějovicích, 2018, 1214-021X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10606 Microbiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.573

RIV identification code

RIV/00216224:14310/18:00102287

Organization unit

Faculty of Science

UT WoS

000440056300012

Keywords in English

Sulfate-reducing bacteria; Dissimilatory sulfate reduction; Inflammatory bowel disease; 8-hydroxyquinolines; Structure-activity relationships
Změněno: 5/4/2020 14:24, doc. Ivan Kushkevych, Ph.D.

Abstract

V originále

An increased number of sulfate-reducing bacteria is often isolated from faeces of patients with gastrointestinal diseases, which can be the cause of the development of bowel inflammation. Frequent use of antibiotics causes the resistance of intestinal microorganisms and ineffective treatment of these diseases. The antimicrobial activity and biological properties of the selected ring-substituted 8-hydroxyquinoline-2-carboxanilides against Desulfovibrio piger Vib-7 were studied. The addition of these compounds in the cultivation medium inhibited the bacterial growth and the process of sulfate reduction dose-dependently. A significant cytotoxic activity under the influence of ring-substituted 8-hydroxyquinoline-2-carboxanilides was determined.

Links

MUNI/A/0906/2016, interní kód MU
Name: Podpora výzkumné činnosti studentů Mikrobiologie a molekulární biotechnologie 1 (Acronym: SVMIK)
Investor: Masaryk University, Category A