Other formats:
BibTeX
LaTeX
RIS
@article{1407571,
author = {Sak, Bohumil and Jandová, Anna and Doležal, Karel and Kváč, Martin and Květoňová, Dana and Hlásková, Lenka and Rost, Michael and Olšanský, Milan and Nurcahyo, Wisnu and Foitová, Ivona},
article_location = {San Diego, USA},
article_number = {October},
doi = {http://dx.doi.org/10.1016/j.exppara.2017.07.014},
keywords = {Molecular detection; Antifungal; Plant extract; Encephalitozoon cuniculi; In vivo},
language = {eng},
issn = {0014-4894},
journal = {Experimental Parasitology},
title = {Effects of selected Indonesian plant extracts on E. cuniculi infection in vivo},
volume = {181},
year = {2017}
}
TY - JOUR
ID - 1407571
AU - Sak, Bohumil - Jandová, Anna - Doležal, Karel - Kváč, Martin - Květoňová, Dana - Hlásková, Lenka - Rost, Michael - Olšanský, Milan - Nurcahyo, Wisnu - Foitová, Ivona
PY - 2017
TI - Effects of selected Indonesian plant extracts on E. cuniculi infection in vivo
JF - Experimental Parasitology
VL - 181
IS - October
SP - 94-101
EP - 94-101
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 00144894
KW - Molecular detection
KW - Antifungal
KW - Plant extract
KW - Encephalitozoon cuniculi
KW - In vivo
N2 - The present study was conducted to evaluate the methanolic extracts from several plant leaves widely used in traditional medicine to cure digestive tract disorders and in the self-medication of wild animals such as non-human primates, namely Archidendron fagifolium, Diospyros sumatrana, Shorea sumatrana, and Piper betle leaves, with regard to their antimicrosporidial activity against Encephalitozoon cuniculi in immunocompetent BALB/c mice determined using molecular detection of microsporidial DNA (qPCR) in various tissues and body fluids of infected, treated mice. Of the plant extracts tested, Diospyros sumatrana provided the most promising results, reducing spore shedding by 88% compared to untreated controls. Moreover, total burden per 1 g of tissue in the D. sumatrana extract-treated group reached 87% reduction compared to untreated controls, which was comparable to the effect of the standard drug, Albendazole. This data represents the baseline necessary for further research focused on determining the structure, activity and modes of action of the active compounds, mainly of D. sumatrana, enabling subsequent development of antimicrosporidial remedies.
ER -
SAK, Bohumil, Anna JANDOVÁ, Karel DOLEŽAL, Martin KVÁČ, Dana KVĚTOŇOVÁ, Lenka HLÁSKOVÁ, Michael ROST, Milan OLŠANSKÝ, Wisnu NURCAHYO and Ivona FOITOVÁ. Effects of selected Indonesian plant extracts on E. cuniculi infection in vivo. \textit{Experimental Parasitology}. San Diego, USA: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017, vol.~181, October, p.~94-101. ISSN~0014-4894. Available from: https://dx.doi.org/10.1016/j.exppara.2017.07.014.
|
