Detailed Information on Publication Record
2017
Self-medication by orang-utans (Pongo pygmaeus) using bioactive properties of Dracaena cantleyi
MORROGH-BERNARD, H. C., Ivona FOITOVÁ, Z. YEEN, P. WILKIN, R. DE MARTIN et. al.Basic information
Original name
Self-medication by orang-utans (Pongo pygmaeus) using bioactive properties of Dracaena cantleyi
Authors
MORROGH-BERNARD, H. C. (360 Indonesia), Ivona FOITOVÁ (203 Czech Republic, guarantor, belonging to the institution), Z. YEEN (360 Indonesia), P. WILKIN (826 United Kingdom of Great Britain and Northern Ireland), R. DE MARTIN (40 Austria), L. RÁROVÁ (203 Czech Republic), K. DOLEŽAL (203 Czech Republic), W. NURCAHYO (360 Indonesia) and M. OLŠANSKÝ (203 Czech Republic)
Edition
Scientific Reports, LONDON, NATURE PUBLISHING GROUP, 2017, 2045-2322
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10613 Zoology
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 4.122
RIV identification code
RIV/00216224:14310/17:00095485
Organization unit
Faculty of Science
UT WoS
000416891400055
Keywords in English
STEROIDAL SAPONINS; CAPUCHIN MONKEYS; BEHAVIOR; CHIMPANZEES
Změněno: 11/4/2018 21:37, Ing. Nicole Zrilić
Abstract
V originále
Animals self-medicate using a variety of plant and arthropod secondary metabolites by either ingesting them or anointing them to their fur or skin apparently to repel ectoparasites and treat skin diseases. In this respect, much attention has been focused on primates. Direct evidence for self-medication among the great apes has been limited to Africa. Here we document self-medication in the only Asian great ape, orang-utans (Pongo pygmaeus), and for the first time, to our knowledge, the external application of an anti-inflammatory agent in animals. The use of leaf extracts from Dracaena cantleyi by orangutan has been observed on several occasions; rubbing a foamy mixture of saliva and leaf onto specific parts of the body. Interestingly, the local indigenous human population also use a poultice of these leaves for the relief of body pains. We present pharmacological analyses of the leaf extracts from this species, showing that they inhibit TNF alpha-induced inflammatory cytokine production (E-selectin, ICAM1, VCAM-1 and IL-6). This validates the topical anti-inflammatory properties of this plant and provides a possible function for its use by orang-utans. This is the first evidence for the deliberate external application of substances with demonstrated bioactive potential for self-medication in great apes.
Links
| GAP505/11/1163, research and development project |
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