| WADDINGTON, John L., Stanislav KATINA, Colm M. P. O’TUATHAIGH and Adrian W. BOWMAN. Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the “Prism” of Schizophrenia. Current Behavioral Neuroscience Reports. Springer, 2017, vol. 4, No 4, p. 322-330. ISSN 2196-2979. Available from: https://dx.doi.org/10.1007/s40473-017-0136-3. |
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@article{1408598,
author = {Waddington, John L. and Katina, Stanislav and O’Tuathaigh, Colm M. P. and Bowman, Adrian W.},
article_number = {4},
doi = {http://dx.doi.org/10.1007/s40473-017-0136-3},
keywords = {Neurodevelopmental disorders; Craniofacial dysmorphology; Schizophrenia; Mouse models; 3D facial imaging; Geometric morphometrics; Asymmetry},
language = {eng},
issn = {2196-2979},
journal = {Current Behavioral Neuroscience Reports},
title = {Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the “Prism” of Schizophrenia},
url = {https://link.springer.com/article/10.1007%2Fs40473-017-0136-3},
volume = {4},
year = {2017}
}
TY - JOUR
ID - 1408598
AU - Waddington, John L. - Katina, Stanislav - O’Tuathaigh, Colm M. P. - Bowman, Adrian W.
PY - 2017
TI - Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the “Prism” of Schizophrenia
JF - Current Behavioral Neuroscience Reports
VL - 4
IS - 4
SP - 322-330
EP - 322-330
PB - Springer
SN - 21962979
KW - Neurodevelopmental disorders
KW - Craniofacial dysmorphology
KW - Schizophrenia
KW - Mouse models
KW - 3D facial imaging
KW - Geometric morphometrics
KW - Asymmetry
UR - https://link.springer.com/article/10.1007%2Fs40473-017-0136-3
L2 - https://link.springer.com/article/10.1007%2Fs40473-017-0136-3
N2 - Purpose of Review In the context of human developmental conditions, we review the conceptualisation of schizophrenia as a neurodevelopmental disorder, the status of craniofacial dysmorphology as a clinically accessible index of brain dysmorphogenesis, the ability of genetically modified mouse models of craniofacial dysmorphology to inform on the underlying dysmorphogenic process and how geometric morphometric techniques in mutant mice can extend quantitative analysis. Recent Findings Mutant mice with disruption of neuregulin-1, a gene associated meta-analytically with risk for schizophrenia, constitute proof-of-concept studies of murine facial dysmorphology in a manner analogous to clinical studies in schizophrenia. Geometric morphometric techniques informed on the topography of facial dysmorphology and identified asymmetry therein. Summary Targeted disruption in mice of genes involved in individual components of developmental processes and analysis of resultant facial dysmorphology using geometric morphometrics can inform on mechanisms of dysmorphogenesis at levels of incisiveness not possible in human subjects.
ER -
WADDINGTON, John L., Stanislav KATINA, Colm M. P. O’TUATHAIGH and Adrian W. BOWMAN. Translational Genetic Modelling of 3D Craniofacial Dysmorphology: Elaborating the Facial Phenotype of Neurodevelopmental Disorders Through the “Prism” of Schizophrenia. \textit{Current Behavioral Neuroscience Reports}. Springer, 2017, vol.~4, No~4, p.~322-330. ISSN~2196-2979. Available from: https://dx.doi.org/10.1007/s40473-017-0136-3.
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