| ANDERKOVÁ, Ľubomíra, Marek BARTOŇ and Irena REKTOROVÁ. Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition. Movement Disorders. HOBOKEN: WILEY, 2017, vol. 32, No 6, p. 917-921, 7 pp. ISSN 0885-3185. Available from: https://dx.doi.org/10.1002/mds.26956. |
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@article{1408660,
author = {Anderková, Ľubomíra and Bartoň, Marek and Rektorová, Irena},
article_location = {HOBOKEN},
article_number = {6},
doi = {http://dx.doi.org/10.1002/mds.26956},
keywords = {striatum; Parkinson's disease; Alzheimer's disease; resting state functional connectivity; cognition},
language = {eng},
issn = {0885-3185},
journal = {Movement Disorders},
title = {Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition},
volume = {32},
year = {2017}
}
TY - JOUR
ID - 1408660
AU - Anderková, Ľubomíra - Bartoň, Marek - Rektorová, Irena
PY - 2017
TI - Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition
JF - Movement Disorders
VL - 32
IS - 6
SP - 917-921
EP - 917-921
PB - WILEY
SN - 08853185
KW - striatum
KW - Parkinson's disease
KW - Alzheimer's disease
KW - resting state functional connectivity
KW - cognition
N2 - Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. Methods: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed. Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. (C) 2017 International Parkinson and Movement Disorder Society
ER -
ANDERKOVÁ, Ľubomíra, Marek BARTOŇ and Irena REKTOROVÁ. Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition. \textit{Movement Disorders}. HOBOKEN: WILEY, 2017, vol.~32, No~6, p.~917-921, 7 pp. ISSN~0885-3185. Available from: https://dx.doi.org/10.1002/mds.26956.
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