Striato-cortical Connections in Parkinson's and Alzheimer's
Diseases: Relation to Cognition

J 2017

Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition

ANDERKOVÁ, Ľubomíra, Marek BARTOŇ and Irena REKTOROVÁ

Basic information

Original name

Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition

Authors

ANDERKOVÁ, Ľubomíra (703 Slovakia, belonging to the institution), Marek BARTOŇ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Movement Disorders, HOBOKEN, WILEY, 2017, 0885-3185

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 8.324

RIV identification code

RIV/00216224:14110/17:00095707

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/mds.26956

UT WoS

000402969400017

Keywords in English

striatum; Parkinson's disease; Alzheimer's disease; resting state functional connectivity; cognition

Abstract

V originále

Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. Methods: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed. Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. (C) 2017 International Parkinson and Movement Disorder Society

Links

LM2015062, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministry of Education, Youth and Sports of the CR

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV15-33854A, research and development project

Name: Efekt intenzivní tanečně-pohybové intervence na kognitivní funkce a změny mozkové plasticity zdravých seniorů a pacientů s mírnou kognitivní poruchou

Citovat

ANDERKOVÁ, Ľubomíra, Marek BARTOŇ and Irena REKTOROVÁ. Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition. Movement Disorders. HOBOKEN: WILEY, 2017, vol. 32, No 6, p. 917-921, 7 pp. ISSN 0885-3185. Available from: https://dx.doi.org/10.1002/mds.26956.

@article{1408660,
   author = {Anderková, Ľubomíra and Bartoň, Marek and Rektorová, Irena},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1002/mds.26956},
   keywords = {striatum; Parkinson's disease; Alzheimer's disease; resting state functional connectivity; cognition},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1408660
AU  - Anderková, Ľubomíra - Bartoň, Marek - Rektorová, Irena
PY  - 2017
TI  - Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition
JF  - Movement Disorders
VL  - 32
IS  - 6
SP  - 917-921
EP  - 917-921
PB  - WILEY
SN  - 08853185
KW  - striatum
KW  - Parkinson's disease
KW  - Alzheimer's disease
KW  - resting state functional connectivity
KW  - cognition
N2  - Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. Methods: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed. Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. (C) 2017 International Parkinson and Movement Disorder Society
ER  -

ANDERKOVÁ, Ľubomíra, Marek BARTOŇ and Irena REKTOROVÁ. Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition. \textit{Movement Disorders}. HOBOKEN: WILEY, 2017, vol.~32, No~6, p.~917-921, 7 pp. ISSN~0885-3185. Available from: https://dx.doi.org/10.1002/mds.26956.

Detailed Information on Publication Record