J 2017

New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC

SHARMA, Anežka, Katarína BÁNYIOVÁ, Jaromír LITERÁK and Pavel ČUPR

Basic information

Original name

New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC

Authors

SHARMA, Anežka (203 Czech Republic, belonging to the institution), Katarína BÁNYIOVÁ (703 Slovakia, belonging to the institution), Jaromír LITERÁK (203 Czech Republic, belonging to the institution) and Pavel ČUPR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Environmental toxicology, Hoboken, USA, WILEY-BLACKWELL, 2017, 1520-4081

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10503 Water resources

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.491

RIV identification code

RIV/00216224:14310/17:00095508

Organization unit

Faculty of Science

DOI

UT WoS

000393799500019

Keywords in English

ethylhexyl methoxycinnamate; trans/cis isomerisation; genotoxicity; probabilistic risk assessment; QIVIVE

Tags

Tags

International impact, Reviewed
Změněno: 9/4/2018 16:26, Ing. Nicole Zrilić

Abstract

V originále

Ethylhexyl methoxycinnamate (EHMC) is a widely used UV filter present in a large number of personal care products (PCPs). Under normal conditions, EHMC occurs in a mixture of two isomers: trans-EHMC and cis-EHMC in a ratio of 99:1. When exposed to sunlight, the trans isomer is transformed to the less stable cis isomer and the efficiency of the UV filter is reduced. To date, the toxicological effects of the cis-EHMC isomer remain largely unknown. We developed a completely new method for preparing cis-EHMC. An EHMC technical mixture was irradiated using a UV lamp and 98% pure cis-EHMC was isolated from the irradiated solution using column chromatography. The genotoxic effects of the isolated cis-EHMC isomer and the nonirradiated trans-EHMC were subsequently measured using two bioassays (SOS chromotest and UmuC test). In the case of trans-EHMC, significant genotoxicity was observed using both bioassays at the highest concentrations (0.5 - 4 mgmL(-1)). In the case of cis-EHMC, significant genotoxicity was only detected using the UmuC test at concentrations of 0.25 - 1 mgmL(-1). Based on these results, the NOEC was calculated for both cis- and trans-EHMC, 0.038 and 0.064 mgmL(-1), respectively. Risk assessment of dermal, oral and inhalation exposure to PCPs containing EHMC was carried out for a female population using probabilistic simulation and by using Quantitative in vitro to in vivo extrapolation (QIVIVE). The risk of cis-EHMC was found to be approximate to 1.7 times greater than trans-EHMC. In the case of cis-EHMC, a hazard index of 1 was exceeded in the 92nd percentile. Based on the observed differences between the isomers, EHMC application in PCPs requires detailed reassessment. Further exploration of the toxicological effects and properties of cis-EHMC is needed in order to correctly predict risks posed to humans and the environment.

Links

GA14-27941S, research and development project
Name: Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici
Investor: Czech Science Foundation
LM2015051, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
LO1214, research and development project
Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)
Investor: Ministry of Education, Youth and Sports of the CR