Investigation of cis-trans isomer dependent
dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate
through stratum corneum in vivo

J 2017

Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo

SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN, Pavel ČUPR et. al.

Basic information

Original name

Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo

Authors

SHARMA, Anežka (203 Czech Republic, belonging to the institution), Katarína BÁNYIOVÁ (703 Slovakia, belonging to the institution), Branislav VRANA (703 Slovakia, belonging to the institution), Ivan JUSTAN (203 Czech Republic) and Pavel ČUPR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Environmental Science and Pollution Research, HEIDELBERG, GERMANY, SPRINGER HEIDELBERG, 2017, 0944-1344

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.800

RIV identification code

RIV/00216224:14310/17:00095511

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1007/s11356-017-0172-2

UT WoS

000414958700026

Keywords in English

Ethylhexyl methoxycinnamate; Personal care products; Cis/trans isomerization; Tape stripping; Dermatotoxicokinetics; Human skin permeation

Abstract

V originále

2-Ethylhexyl methoxycinnamate (EHMC) is one of the most used ultraviolet filters in personal care products. It undergoes cis/trans isomerization in sunlight, and there is limited toxicological understanding of the effects of the cis-isomer. It is known that two geometric isomers of one compound can have different physico-chemical properties and effects. However, there are no studies focusing on toxicokinetics of EHMC isomerization products to compare their potential difference in dermal exposure to cis-EHMC and trans-EHMC due to the difference in their dermatotoxicokinetics. In this study, dermal absorption of the parental trans-EHMC and its cis isomer was studied. A commercially available sunscreen lotion containing trans-EHMC and spiked with laboratory-prepared cis-EHMC was locally applied on the forearm skin of two volunteers. After 8 h of skin exposure, the stratum corneum (SC) layer was removed by tape stripping. The removed thickness of the SC was determined spectrophotometrically using a total protein assay. The concentration of both isomers in the removed SC was measured by HPLC-DAD. A new diffusion and permeability coefficient of both EHMC isomers in SC were determined by Fick's second law of diffusion in vivo. The difference in dermatotoxicokinetic parameters between the two isomers was not statistically significant. However, separate toxicological studies of isomeric forms and the determination of their dermatotoxicokinetic parameters are crucial for refinement of human risk assessment.

Links

GA14-27941S, research and development project

Name: Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici

Investor: Czech Science Foundation

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

LO1214, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN and Pavel ČUPR. Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo. Environmental Science and Pollution Research. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2017, vol. 24, No 32, p. 25061-25070. ISSN 0944-1344. Available from: https://dx.doi.org/10.1007/s11356-017-0172-2.

@article{1408677,
   author = {Sharma, Anežka and Bányiová, Katarína and Vrana, Branislav and Justan, Ivan and Čupr, Pavel},
   article_location = {HEIDELBERG, GERMANY},
   article_number = {32},
   doi = {http://dx.doi.org/10.1007/s11356-017-0172-2},
   keywords = {Ethylhexyl methoxycinnamate; Personal care products; Cis/trans isomerization; Tape stripping; Dermatotoxicokinetics; Human skin permeation},
   language = {eng},
   issn = {0944-1344},
   journal = {Environmental Science and Pollution Research},
   title = {Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo},
   url = {https://link.springer.com/article/10.1007%2Fs11356-017-0172-2},
   volume = {24},
   year = {2017}
}

TY  - JOUR
ID  - 1408677
AU  - Sharma, Anežka - Bányiová, Katarína - Vrana, Branislav - Justan, Ivan - Čupr, Pavel
PY  - 2017
TI  - Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo
JF  - Environmental Science and Pollution Research
VL  - 24
IS  - 32
SP  - 25061-25070
EP  - 25061-25070
PB  - SPRINGER HEIDELBERG
SN  - 09441344
KW  - Ethylhexyl methoxycinnamate
KW  - Personal care products
KW  - Cis/trans isomerization
KW  - Tape stripping
KW  - Dermatotoxicokinetics
KW  - Human skin permeation
UR  - https://link.springer.com/article/10.1007%2Fs11356-017-0172-2
L2  - https://link.springer.com/article/10.1007%2Fs11356-017-0172-2
N2  - 2-Ethylhexyl methoxycinnamate (EHMC) is one of the most used ultraviolet filters in personal care products. It undergoes cis/trans isomerization in sunlight, and there is limited toxicological understanding of the effects of the cis-isomer. It is known that two geometric isomers of one compound can have different physico-chemical properties and effects. However, there are no studies focusing on toxicokinetics of EHMC isomerization products to compare their potential difference in dermal exposure to cis-EHMC and trans-EHMC due to the difference in their dermatotoxicokinetics. In this study, dermal absorption of the parental trans-EHMC and its cis isomer was studied. A commercially available sunscreen lotion containing trans-EHMC and spiked with laboratory-prepared cis-EHMC was locally applied on the forearm skin of two volunteers. After 8 h of skin exposure, the stratum corneum (SC) layer was removed by tape stripping. The removed thickness of the SC was determined spectrophotometrically using a total protein assay. The concentration of both isomers in the removed SC was measured by HPLC-DAD. A new diffusion and permeability coefficient of both EHMC isomers in SC were determined by Fick's second law of diffusion in vivo. The difference in dermatotoxicokinetic parameters between the two isomers was not statistically significant. However, separate toxicological studies of isomeric forms and the determination of their dermatotoxicokinetic parameters are crucial for refinement of human risk assessment.
ER  -

SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN and Pavel ČUPR. Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo. \textit{Environmental Science and Pollution Research}. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2017, vol.~24, No~32, p.~25061-25070. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-017-0172-2.

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