| SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN and Pavel ČUPR. Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo. Environmental Science and Pollution Research. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2017, vol. 24, No 32, p. 25061-25070. ISSN 0944-1344. Available from: https://dx.doi.org/10.1007/s11356-017-0172-2. |
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@article{1408677,
author = {Sharma, Anežka and Bányiová, Katarína and Vrana, Branislav and Justan, Ivan and Čupr, Pavel},
article_location = {HEIDELBERG, GERMANY},
article_number = {32},
doi = {http://dx.doi.org/10.1007/s11356-017-0172-2},
keywords = {Ethylhexyl methoxycinnamate; Personal care products; Cis/trans isomerization; Tape stripping; Dermatotoxicokinetics; Human skin permeation},
language = {eng},
issn = {0944-1344},
journal = {Environmental Science and Pollution Research},
title = {Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo},
url = {https://link.springer.com/article/10.1007%2Fs11356-017-0172-2},
volume = {24},
year = {2017}
}
TY - JOUR
ID - 1408677
AU - Sharma, Anežka - Bányiová, Katarína - Vrana, Branislav - Justan, Ivan - Čupr, Pavel
PY - 2017
TI - Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo
JF - Environmental Science and Pollution Research
VL - 24
IS - 32
SP - 25061-25070
EP - 25061-25070
PB - SPRINGER HEIDELBERG
SN - 09441344
KW - Ethylhexyl methoxycinnamate
KW - Personal care products
KW - Cis/trans isomerization
KW - Tape stripping
KW - Dermatotoxicokinetics
KW - Human skin permeation
UR - https://link.springer.com/article/10.1007%2Fs11356-017-0172-2
L2 - https://link.springer.com/article/10.1007%2Fs11356-017-0172-2
N2 - 2-Ethylhexyl methoxycinnamate (EHMC) is one of the most used ultraviolet filters in personal care products. It undergoes cis/trans isomerization in sunlight, and there is limited toxicological understanding of the effects of the cis-isomer. It is known that two geometric isomers of one compound can have different physico-chemical properties and effects. However, there are no studies focusing on toxicokinetics of EHMC isomerization products to compare their potential difference in dermal exposure to cis-EHMC and trans-EHMC due to the difference in their dermatotoxicokinetics. In this study, dermal absorption of the parental trans-EHMC and its cis isomer was studied. A commercially available sunscreen lotion containing trans-EHMC and spiked with laboratory-prepared cis-EHMC was locally applied on the forearm skin of two volunteers. After 8 h of skin exposure, the stratum corneum (SC) layer was removed by tape stripping. The removed thickness of the SC was determined spectrophotometrically using a total protein assay. The concentration of both isomers in the removed SC was measured by HPLC-DAD. A new diffusion and permeability coefficient of both EHMC isomers in SC were determined by Fick's second law of diffusion in vivo. The difference in dermatotoxicokinetic parameters between the two isomers was not statistically significant. However, separate toxicological studies of isomeric forms and the determination of their dermatotoxicokinetic parameters are crucial for refinement of human risk assessment.
ER -
SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN and Pavel ČUPR. Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo. \textit{Environmental Science and Pollution Research}. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2017, vol.~24, No~32, p.~25061-25070. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-017-0172-2.
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