| TESEI, Giulio, Erik HELLSTRAND, Kalyani SANAGAVARAPU, Sara LINSE, Emma SPARR, Robert VÁCHA and Mikael LUND. Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces. Langmuir. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2018, vol. 34, No 4, p. 1266-1273. ISSN 0743-7463. Available from: https://dx.doi.org/10.1021/acs.langmuir.7b03155. |
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@article{1409325,
author = {Tesei, Giulio and Hellstrand, Erik and Sanagavarapu, Kalyani and Linse, Sara and Sparr, Emma and Vácha, Robert and Lund, Mikael},
article_location = {WASHINGTON},
article_number = {4},
doi = {http://dx.doi.org/10.1021/acs.langmuir.7b03155},
keywords = {QUARTZ-CRYSTAL MICROBALANCE; ATOMIC-RESOLUTION STRUCTURE; POISSON-BOLTZMANN THEORY; AIR-WATER-INTERFACE; ALPHA-SYNUCLEIN; MONTE-CARLO; STRUCTURAL BASIS; LIPID-MEMBRANES; BETA-PEPTIDE; FIBRILS},
language = {eng},
issn = {0743-7463},
journal = {Langmuir},
title = {Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces},
url = {https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03155},
volume = {34},
year = {2018}
}
TY - JOUR
ID - 1409325
AU - Tesei, Giulio - Hellstrand, Erik - Sanagavarapu, Kalyani - Linse, Sara - Sparr, Emma - Vácha, Robert - Lund, Mikael
PY - 2018
TI - Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces
JF - Langmuir
VL - 34
IS - 4
SP - 1266-1273
EP - 1266-1273
PB - AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN - 07437463
KW - QUARTZ-CRYSTAL MICROBALANCE
KW - ATOMIC-RESOLUTION STRUCTURE
KW - POISSON-BOLTZMANN THEORY
KW - AIR-WATER-INTERFACE
KW - ALPHA-SYNUCLEIN
KW - MONTE-CARLO
KW - STRUCTURAL BASIS
KW - LIPID-MEMBRANES
KW - BETA-PEPTIDE
KW - FIBRILS
UR - https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03155
N2 - Amyloid aggregates are associated with a range of human neuro-degenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to aggregate size and preferential adsorption of smaller aggregates over larger ones. Our findings describe a general phenomenon with implications for stiff polyions and rodlike particles that are electrostatically attracted to a surface.
ER -
TESEI, Giulio, Erik HELLSTRAND, Kalyani SANAGAVARAPU, Sara LINSE, Emma SPARR, Robert VÁCHA and Mikael LUND. Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces. \textit{Langmuir}. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2018, vol.~34, No~4, p.~1266-1273. ISSN~0743-7463. Available from: https://dx.doi.org/10.1021/acs.langmuir.7b03155.
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